Thiazole Orange−Peptide Conjugates: Sensitivity of DNA Binding to Chemical Structure
| Autor: | Kerry P. Mahon, Shana O. Kelley, Jay R. Carreon |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Models
Molecular chemistry.chemical_classification Molecular Structure Stereochemistry Chemical structure Organic Chemistry Peptide DNA Biochemistry Fluorescence Structure-Activity Relationship Thiazoles chemistry.chemical_compound chemistry Quinolines Molecule Structure–activity relationship Amino Acid Sequence Benzothiazoles Physical and Theoretical Chemistry Peptides Peptide sequence Fluorescent Dyes Conjugate |
| Zdroj: | Organic Letters. 6:517-519 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol0362818 |
| Popis: | [structure: see text] Derivatives of the highly fluorescent and DNA-binding dye thiazole orange (TO) are described that feature appended peptides. Functionalization of TO can be achieved at either of the endocyclic nitrogens, and the photophysical properties and DNA-binding modes are sensitive to the position of the tethered peptide. A series of TO-peptide conjugates are described, demonstrating the utility of a solid-phase synthesis approach to their preparation and illustrating how the photophysical and DNA-binding properties of the compounds are influenced by chemical structure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|