Endothelial dysfunction during long-term follow-up in children with STEC hemolytic-uremic syndrome

Autor: Lars Pape, Dieter Haffner, Laura Sollmann, Martin Kreuzer, Dagmar-Christiane Fischer, Stephan Ruben, Maren Leifheit-Nestler
Rok vydání: 2017
Předmět:
Male
Nephrology
Pathology
Time Factors
030232 urology & nephrology
030204 cardiovascular system & hematology
urologic and male genital diseases
Carotid Intima-Media Thickness
0302 clinical medicine
Endothelial dysfunction
Child
Pulse wave velocity
Escherichia coli Infections
Skin
Shiga-Toxigenic Escherichia coli
Age Factors
Acute kidney injury
Acute Kidney Injury
Blood Pressure Monitoring
Ambulatory
Child
Preschool
Hypertension
cardiovascular system
Cardiology
Female
medicine.symptom
Glomerular Filtration Rate
medicine.medical_specialty
Ambulatory blood pressure
Adolescent
Renal function
Pulse Wave Analysis
Angiopoietin-2
03 medical and health sciences
Renal Dialysis
Internal medicine
Angiopoietin-1
medicine
Albuminuria
Humans
business.industry
Infant
medicine.disease
Cross-Sectional Studies
Intima-media thickness
Hemolytic-Uremic Syndrome
Microvessels
Pediatrics
Perinatology and Child Health
Endothelium
Vascular
business
Follow-Up Studies
Zdroj: Pediatric Nephrology. 32:1005-1011
ISSN: 1432-198X
0931-041X
DOI: 10.1007/s00467-016-3574-3
Popis: Shiga-toxin-producing Escherichia coli (STEC)-associated hemolytic-uremic syndrome (HUS) is a major cause of acute kidney injury (AKI), especially in children. Its long-term outcome with respect to endothelial damage remains largely elusive. This was a cross-sectional study in 26 children who had suffered from STEC-HUS in the past and achieved a complete recovery of renal function (eGFR >90 ml/min/1.73 m2). Skin microcirculation after local heating was assessed by laser Doppler fluximetry, carotid-femoral pulse wave velocity (PWV), carotid intima media thickness (cIMT), 24-h ambulatory blood pressure, and angiopoietin (Ang) 1 and 2 serum levels after a median follow-up period of 6.1 years. The results were compared to those of healthy controls. All patients were normotensive, mean eGFR was 102 (range 91–154) ml/min/1.73 m2, and 13 of the 26 patients showed albuminuria. Endothelial dysfunction was present in 13 patients, and the mean serum Ang2/Ang1 ratio was increased compared to healthy children (each p
Databáze: OpenAIRE
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