Approaches to Study the Role of S100 Proteins in Calcium-Dependent Cellular Responses
| Autor: | D. B. Zimmer, Linda J. Van Eldik |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
chemistry.chemical_classification
GTPase-activating protein Cell growth Effector Calcium-Binding Proteins S100 Proteins Signal transducing adaptor protein Motility chemistry.chemical_element S100 Calcium Binding Protein beta Subunit Biology Calcium Rats Cell biology Enzyme chemistry Second messenger system Genetics Animals Tissue Distribution Animal Science and Zoology Nerve Growth Factors Biomarkers Food Science |
| Zdroj: | Journal of Dairy Science. 71:2028-2034 |
| ISSN: | 0022-0302 |
| DOI: | 10.3168/jds.s0022-0302(88)79778-7 |
| Popis: | Calcium is necessary for the optimal growth and cellular functions of most living organisms. For example, Ca is involved in the processes of muscle contraction, stimulus-secretion coupling, bone formation, blood clotting, cell proliferation and motility, and fertilization. Many regulatory actions of Ca are mediated through Ca-binding proteins. Calcium-modulated proteins are a subclass of Ca-binding proteins that are thought to be the major signal transducers of Ca acting as a cellular second messenger. Most Ca-modulated proteins are not enzymes but are effector proteins capable of transducing a Ca signal into a biological response by their ability to bind Ca reversibly and modulate the activity of other proteins in a Ca-dependent manner. This review focuses on a set of Ca-modulated proteins, the S100 proteins, and their possible roles in mediating Ca-dependent cellular events. |
| Databáze: | OpenAIRE |
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