Insulin-like growth factor–I in women with hydatidiform mole and in normal pregnancy
| Autor: | Inga Wihman, Kjell Carlström, Margareta Faxén |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Molar medicine.medical_specialty Placenta medicine.medical_treatment Insulin-like growth factor Pregnancy Internal medicine Blood plasma Mole medicine Humans RNA Messenger Insulin-Like Growth Factor I business.industry Obstetrics and Gynecology Radioimmunoassay Hydatidiform Mole medicine.disease medicine.anatomical_structure Endocrinology Uterine Neoplasms Solution hybridization Female business |
| Zdroj: | Obstetrics & Gynecology. 92:431-434 |
| ISSN: | 0029-7844 |
| Popis: | Objective: To compare molar and placental tissue insulin-like growth factor–I (IGF-I) levels and IGF-I messenger RNA (mRNA) expression and maternal serum IGF-I levels in molar and normal pregnancies of the same gestational length. Methods: Tissue and serum total IGF-I were measured by radioimmunoassay, and tissue IGF-I mRNA expression was measured by a solution hybridization technique in samples from seven patients with hydatidiform mole in gestational weeks 8 through 14 and from 12 women with normal placentas undergoing induced abortion during weeks 8 through 12. Results: Tissue and serum total IGF-I levels and tissue IGF-I mRNA expression were significantly lower in molar pregnancies than in pregnancies with normal placenta. Conclusion: The lower levels of both IGF-I mRNA and of the IGF-I protein itself in hydatidiform mole indicates that the regulation of expression of IGF-I is on the transcriptional level. This finding may reflect a decreased production of the placental growth hormone variant in molar tissue. |
| Databáze: | OpenAIRE |
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