Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes
| Jazyk: | English |
|---|---|
| ISSN: | 0960-314X |
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc0e253ca751a1a9b87324bb37dc713 https://doi.org/10.1097/00008571-200412000-00005 |
| Rights: | RESTRICTED |
| Přírůstkové číslo: | edsair.doi.dedup.....4cc0e253ca751a1a9b87324bb37dc713 |
| Autor: | Christelle Foucher, Stephanie Rattier, David M. Flavell, John J.P. Kastelein, Jean-Claude Ansquer, Philippa J. Talmud, Steve E. Humphries, Simon N. Pimstone, George Steiner, Amir F. Ayyobi, Jiri Frohlich |
| Přispěvatelé: | Amsterdam Cardiovascular Sciences, Vascular Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Apolipoprotein E
Male medicine.medical_specialty Apolipoprotein E2 Type 2 diabetes White People Body Mass Index chemistry.chemical_compound Apolipoproteins E Fenofibrate Internal medicine Diabetes mellitus Cholesterylester transfer protein Genetics medicine Humans PPAR alpha General Pharmacology Toxicology and Pharmaceutics Triglycerides Glycoproteins Hypolipidemic Agents Polymorphism Genetic biology Triglyceride Cholesterol HDL Cholesterol LDL Middle Aged medicine.disease Introns Cholesterol Ester Transfer Proteins Lipoprotein Lipase Endocrinology Cholesterol chemistry Diabetes Mellitus Type 2 biology.protein Female Hepatic lipase Carrier Proteins medicine.drug |
| Zdroj: | Pharmacogenetics, 14(12), 823-829. Lippincott Williams and Wilkins |
| ISSN: | 0960-314X |
| Popis: | Objective The association between polymorphisms in candidate genes related to lipoprotein metabolism and the reduction in plasma triglyceride (TG) in response to fenofibrate treatment was evaluated in subjects with type 2 diabetes treated with micronized fenofibrate (200 mg/day) for at least 3 years in the Diabetes Atherosclerosis Intervention Study. Methods The cholesteryl ester transfer protein Taq1B, LPL S447X, hepatic lipase -514 C-->T, peroxisome-proliferator-activated receptors alpha (PPARA) L162V and G/C intron 7 polymorphisms and the apolipoprotein E2/E3/E4 alleles were genotyped using PCR and restriction enzyme digestion. Subjects were divided into high TG-responders (with >30% TG relative reduction after treatment) and low TG-responders. Results The frequency of the PPARA intron 7 G/G genotype was higher in high TG-responders than in low TG-responders (85% vs. 69%, P 30% after fenofibrate treatment in patients with type 2 diabetes. (C) 2004 Lippincott Williams Wilkins |
| Databáze: | OpenAIRE |
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