Distribution of 13-valent pneumococcal conjugate vaccine Streptococcus pneumoniae serotypes in US adults aged ≥50 years with community-acquired pneumonia
| Autor: | Paul C. McGovern, Robert Sherwin, Thomas M. File, Sharon Gray, Jay Purdy, Ronika Alexander, Peter Paradiso, Jay Graepel, Michael W. Pride |
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| Rok vydání: | 2013 |
| Předmět: |
Serotype
Pneumococcal serotypes Male medicine.medical_specialty medicine.disease_cause Pneumococcal conjugate vaccine Pneumococcal Infections Pneumococcal Vaccines Community-acquired pneumonia Antigen Species Specificity Polysaccharides Internal medicine Streptococcus pneumoniae medicine Prevalence Immunology and Allergy Humans Prospective Studies Serotyping Aged Demography Aged 80 and over Cross Infection Vaccines Conjugate business.industry Pneumococcal 7-Valent Conjugate Vaccine Middle Aged medicine.disease Hospitals United States respiratory tract diseases Community-Acquired Infections Pneumonia Infectious Diseases Cross-Sectional Studies Immunology Female business medicine.drug |
| Zdroj: | The Journal of infectious diseases. 208(11) |
| ISSN: | 1537-6613 |
| Popis: | Background. Streptococcus pneumoniae causes a substantial proportion of community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP) in the United States. Limited data are available regarding the pneumococcal serotypes causing CAP and HCAP. Methods. Adults aged ≥50 years presenting to participating US hospitals with radiographically confirmed pneumonia between February 2010 and September 2011 were screened for inclusion. S. pneumoniae was identified using microbiological cultures, BinaxNOW® S. pneumoniae assay, or urine antigen detection (UAD) assay capable of detecting 13-valent pneumococcal conjugate vaccine (PCV13)–associated serotypes. Results. Among 710 subjects enrolled, the median age was 65.4 years; 54.2% of subjects were male, 22.4% of radiographically confirmed pneumonia cases were considered HCAP, and 96.6% of subjects were hospitalized. S. pneumoniae was detected in 98 subjects (13.8%) by any test, and PCV13-associated serotype(s) were identified by UAD in 78 (11.0%). Serotype 19A was most prevalent, followed by 7F/A, 3, and 5. Serotypes associated with 7valent pneumococcal conjugate vaccine (PCV7) accounted for 25% of UAD-positive isolates. Conclusions. Pneumococcal serotypes causing noninvasive pneumonia in adults may differ significantly from those causing invasive disease, with PCV7-associated serotypes overrepresented. Serotype 5, rarely seen in contemporary surveillance of invasive disease in the United States, substantially contributed to the observed cases of S. pneumoniae–positive CAP or HCAP. |
| Databáze: | OpenAIRE |
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