The Updating of Biological Functions of Methyltransferase SETDB1 and Its Relevance in Lung Cancer and Mesothelioma
| Autor: | Liangliang Xu, Boshu Sun, Limin Chen, Wen-Bin Ou, Li Yuan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Mesothelioma Methyltransferase Lung Neoplasms QH301-705.5 Review Biology Catalysis Inorganic Chemistry 03 medical and health sciences Histone H3 0302 clinical medicine Histone methylation medicine SETDB1 Animals Humans Epigenetics Biology (General) Physical and Theoretical Chemistry Lung cancer QD1-999 Molecular Biology Spectroscopy Regulation of gene expression function Organic Chemistry Cancer General Medicine Histone-Lysine N-Methyltransferase medicine.disease Computer Science Applications Chemistry lung cancer 030104 developmental biology 030220 oncology & carcinogenesis DNA methylation Cancer research methyltransferase |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 7416, p 7416 (2021) |
| ISSN: | 1422-0067 |
| Popis: | SET domain bifurcated 1 (SETDB1) is a histone H3 lysine 9 (H3K9) methyltransferase that exerts important effects on epigenetic gene regulation. SETDB1 complexes (SETDB1-KRAB-KAP1, SETDB1-DNMT3A, SETDB1-PML, SETDB1-ATF7IP-MBD1) play crucial roles in the processes of histone methylation, transcriptional suppression and chromatin remodelling. Therefore, aberrant trimethylation at H3K9 due to amplification, mutation or deletion of SETDB1 may lead to transcriptional repression of various tumour-suppressing genes and other related genes in cancer cells. Lung cancer is the most common type of cancer worldwide in which SETDB1 amplification and H3K9 hypermethylation have been indicated as potential tumourigenesis markers. In contrast, frequent inactivation mutations of SETDB1 have been revealed in mesothelioma, an asbestos-associated, locally aggressive, highly lethal, and notoriously chemotherapy-resistant cancer. Above all, the different statuses of SETDB1 indicate that it may have different biological functions and be a potential diagnostic biomarker and therapeutic target in lung cancer and mesothelioma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|