Possible role of the stomach in enteroinsular axis in rats
| Autor: | Tazue Hoshino, Tatsuo Takeuchi, Tadasu Ikeda, Masato Tominaga, Katsumi Fujiyama, Hiroto Mashiba |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Biology Injections Endocrinology Phentolamine Digestive System Physiological Phenomena Internal medicine Insulin Secretion medicine Animals Insulin Mannitol Amino Acids Stomach digestive oral and skin physiology Rats Inbred Strains Metabolism Carbohydrate Cannula Rats Glucose medicine.anatomical_structure Tonicity medicine.drug |
| Zdroj: | Metabolism. 39:1259-1262 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(90)90180-k |
| Popis: | To elucidate the possible role of the stomach in enteroinsular axis, rats had both an inflow gastric cannula and an outflow diversion cannula and a duodenal inflow cannula. The effects of intragastric infusion of glucose (1 mL in 10% solution) or mannitol (1 mL in 10% solution) on blood glucose and plasma insulin responses to subsequent intraduodenal glucose (1.5 g/kg in 10% solution) or amino acids (1.0 g/kg in 10% solution) infusion were investigated. Blood glucose and plasma insulin responses to intraduodenal amino acids were not altered by intragastric infusion of glucose or mannitol. However, higher blood glucose and lower plasma insulin responses to intraduodenal glucose were observed in the rat with intragastric infusion of glucose or mannitol compared with controls (intragastric infusion of distilled water). This phenomenon was abolished in the rat with preadministration of phentolamine. These results suggest that intragastric tonicity may suppress glucose-induced insulin secretion, probably through the α-adrenergic mechanism in the rat. |
| Databáze: | OpenAIRE |
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