IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus
| Autor: | Reena Kapadia, Joseph M. Baron, Mary Smaron, Anthony Chang, Farzan Mahmood, Suncica Volkov, Deborah Manst, Maria Badaracco, Nadera J. Sweiss, Tara Adhikari, Jerrold S. Levine, Ronghai Bo |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Immunoglobulin A
Adult Male Science Rheumatology/Imaging and Biomarkers Comorbidity Young Adult Immunity immune system diseases Thromboembolism Beta 2-Glycoprotein I Medicine Humans Lupus Erythematosus Systemic cardiovascular diseases skin and connective tissue diseases neoplasms Immunity Mucosal Rheumatology/Autoimmunity Autoimmune and Inflammatory Diseases Aged Autoantibodies Retrospective Studies Multidisciplinary Lupus erythematosus biology business.industry Autoantibody Middle Aged medicine.disease Isotype beta 2-Glycoprotein I Rheumatology/Systemic Lupus Erythematosos Immunology biology.protein Female Disease Susceptibility Antibody business Anti-SSA/Ro autoantibodies Research Article |
| Zdroj: | PLoS ONE, Vol 5, Iss 8, p e12280 (2010) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | BackgroundThe clinical utility of testing for antiphospholipid antibodies (aPL) of IgA isotype remains controversial.Methodology/principal findingsTo address this issue, we reasoned that if IgA aPL contribute to the clinical manifestations of the antiphospholipid syndrome, then an association with thromboembolic events should manifest in patients whose only aPL is of IgA isotype. We performed a retrospective chart review of 56 patients (31 with systemic lupus erythematosus [SLE] and 25 without SLE) whose only positive aPL was IgA anti-beta2-glycoprotein I (isolated IgA anti-beta2GPI) and compared their clinical features with 56 individually matched control patients without any aPL. Patients with isolated IgA anti-beta2GPI had a significantly increased number of thromboembolic events, as compared to controls. When patients were stratified into those with and without SLE, the association between isolated IgA anti-beta2GPI and thromboembolic events persisted for patients with SLE, but was lost for those without SLE. Titers of IgA anti-beta2GPI were significantly higher in SLE patients who suffered a thromboembolic event. Among patients with isolated IgA anti-beta2GPI, there was an increased prevalence of diseases or morbidities involving organs of mucosal immunity (i.e., gastrointestinal system, pulmonary system, and skin).Conclusions/significanceThe presence of isolated IgA anti-beta2GPI is associated with an increased risk of thromboembolic events, especially among patients with SLE. IgA anti-beta2GPI is associated with an increased prevalence of morbidities involving organs of mucosal immunity. |
| Databáze: | OpenAIRE |
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