Chromosome- and plasmid-mediated gentamicin resistance in Staphylococcus aureus encoded by Tn4001
| Autor: | L. J. Messerotti, Ronald A. Skurray, Matthew T. Gillespie, B. R. Lyon |
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| Rok vydání: | 1987 |
| Předmět: |
DNA
Bacterial Microbiology (medical) Transposable element Staphylococcus aureus Kanamycin Resistance R Factors Biology medicine.disease_cause Microbiology Transposition (music) Nucleic acid thermodynamics chemistry.chemical_compound Plasmid medicine Nucleic Acid Hybridization Chromosome Drug Resistance Microbial DNA Restriction Enzymes General Medicine Chromosomes Bacterial chemistry DNA Transposable Elements Gentamicins DNA |
| Zdroj: | Journal of Medical Microbiology. 24:139-144 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/00222615-24-2-139 |
| Popis: | DNA sequences corresponding to the 4.7-kb gentamicin, tobramycin and kanamycin resistance (GmrTmrKmr) transposon Tn4001 have been detected on a series of nine structurally-related plasmids that mediate this phenotype in Australian isolates of Staphylococcus aureus. Tn4001 sequences have also been demonstrated on the chromosomes of GmrTmrKmr isolates that do not possess these plasmids, and the exhibited diversity of chromosomal sites occupied by this element implies that Tn4001 has transposed to the chromosome on numerous occasions in vivo. These results suggest that the rapid emergence of nosocomial GmrTmrKmr S. aureus in the early 1980s may have been the result of the transposition of Tn4001 from a chromosomal site to a readily disseminated plasmid. |
| Databáze: | OpenAIRE |
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