Differential release of estradiol from immobilized estrogen receptors by p-sec-amylphenol: evidence for a functional microheterogeneity of estrogen receptors
| Autor: | Mueller Gc, Kim Uh, Van Oosbree Tr |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Estrogen receptor In Vitro Techniques Cytosol Phenols Internal medicine medicine Animals Receptor Estrogen receptor beta Pharmacology Estradiol Chemistry Sepharose Uterus Affinities Rats Endocrinology Receptors Estrogen Estrogen Liberation Estrogen-related receptor gamma Female Rabbits Estrogen receptor alpha hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of receptor research. 4(7) |
| ISSN: | 0197-5110 |
| Popis: | 3H-Estradiol-estrogen receptor complexes were adsorbed on a column of heparin-agarose and subjected to a gradient of increasing concentrations of p-sec-amylphenol. At least five peaks of released 3H-estradiol were observed—demonstrating the existence of subsets of heparin-immobilized receptors with different affinities for estradiol. This finding is presented as further evidence for a functional microheterogeneity among estrogen receptors. The origin of the observed differences in estrogen receptors and possible relevance of the findings to receptor-mediated responses are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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