Pharmacokinetics of artesunate alone and in combination with sulfadoxine/pyrimethamine in healthy Sudanese volunteers
| Autor: | Sakina Babikir Elamin, Kamal M. Matar, Abdelmoneim Awad |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Volunteers Sulfadoxine medicine.medical_treatment Plasmodium falciparum Dihydroartemisinin Administration Oral Artesunate Pharmacology Sudan chemistry.chemical_compound Antimalarials Young Adult Pharmacokinetics Virology parasitic diseases Medicine Humans Malaria Falciparum Active metabolite Cross-Over Studies business.industry Articles Crossover study Sulfadoxine/pyrimethamine Artemisinins Drug Combinations Infectious Diseases Pyrimethamine chemistry Parasitology Drug Therapy Combination Female business medicine.drug |
| Zdroj: | The American journal of tropical medicine and hygiene. 90(6) |
| ISSN: | 1476-1645 |
| Popis: | Artesunate (AS) in combination with sulfadoxine/pyrimethamine (SP) is the first-line therapy for management of uncomplicated Plasmodium falciparum malaria in Sudan. The objective of this study was to assess the potential impact of SP on the pharmacokinetics of AS and its active metabolite, dihydroartemisinin (DHA), in healthy adults. A single-dose, randomized, open-label, crossover study design with a washout period of three weeks was performed with 16 volunteers. After oral administration of AS alone or in combination with SP, Tmax values of AS and DHA were significantly prolonged in the combination group (P < 0.05). However, there was no significant effect on the other pharmacokinetic parameters (P > 0.05). The t1/2 values of AS and DHA were significantly higher in females than in males (P < 0.05). The present findings suggest that co-administration of SP with AS has no clinically relevant impact on the pharmacokinetics of AS or DHA in healthy persons. |
| Databáze: | OpenAIRE |
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