Identification and Analysis of LSD Derivatives in Illegal Products as Paper Sheet
| Autor: | Takashi Hakamatsuka, Rie Tanaka, Maiko Kawamura, Ruri Kikura-Hanajiri |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Paper
Pharmacology Paper sheet Magnetic Resonance Spectroscopy Medical device Illicit Drugs medicine.drug_class Chemistry Pharmaceutical Science Gas Chromatography-Mass Spectrometry Mass Spectrometry Designer Drugs Designer drug Lysergic Acid Diethylamide Spectrometry Fluorescence Lysergamide medicine Organic chemistry Extraction methods Chromatography Liquid Lysergic acid diethylamide medicine.drug |
| Zdroj: | YAKUGAKU ZASSHI. 140:739-750 |
| ISSN: | 1347-5231 0031-6903 |
| DOI: | 10.1248/yakushi.19-00230 |
| Popis: | To prevent the abuse of new psychoactive substances (NPS), a total of 2372 substances and two plants are controlled as "Designated Substances" in Japan as of September 2019. Although the distribution of these substances has decreased for the past three years, newly-emerged NPS are still being found. In this study, we detected four lysergic acid diethylamide (LSD) derivatives as designer drugs from four paper sheet products, which were obtained from 2014 to 2017 in Japan. The compounds were identified as 4-Acetyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (ALD-52), N,N,7-triethyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (ETH-LAD), 7-Allyl-N,N-diethyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (AL-LAD), N,N-diethyl-7-methyl-4-propionyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (1P-LSD), by GC-MS, LC-MS, LC-Q-TOF-MS and NMR analyses. Further, we studied the extraction methods of LSD derivatives from paper sheet, and the analytical conditions of GC-MS, LC-MS and LC-FL(fluorescence). Among LSD derivatives, 1P-LSD have been controlled as designated substances (Shitei Yakubutsu) under the Pharmaceutical and Medical Device Act in Japan since April 2016. For the legislation of the other derivatives identified in this study, the evaluation of their pharmacological properties are now in progress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|