Treatment of late-life schizophrenia with neuroleptics
| Autor: | Patricia L. Gilbert, Neal A. Kline, Jonathan P. Lacro, Joan Kline, Dilip V. Jeste |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Longitudinal study medicine.medical_specialty Pediatrics Psychosis Dyskinesia Drug-Induced Dose Neuropsychological Tests Tardive dyskinesia mental disorders medicine Humans Cumulative incidence Significant risk Risk factor Psychiatry Aged Neurologic Examination Dose-Response Relationship Drug Middle Aged medicine.disease Substance Withdrawal Syndrome Psychiatry and Mental health Schizophrenia Female Schizophrenic Psychology Psychology Antipsychotic Agents Follow-Up Studies |
| Zdroj: | Schizophrenia bulletin. 19(4) |
| ISSN: | 0586-7614 |
| Popis: | There is a dearth of literature on the effects of neuroleptics in older schizophrenia patients. In this article, we review the available literature and present findings from our own studies. Neuroleptics are effective in the treatment of late-life schizophrenia, although older patients generally need lower dosages than younger subjects. Neuroleptics, however, carry a relatively high risk of side effects such as tardive dyskinesia (TD) in middle-aged and elderly patients. By the end of 1 year of a prospective longitudinal study of neuroleptic treatment, we found a 26 percent cumulative incidence of TD among schizophrenia patients over age 45. If neuroleptics are withdrawn, there is a significant risk of a schizophrenic relapse; however, that risk is no greater in older patients than in younger ones. We offer clinical recommendations for the use of neuroleptics in the treatment of late-life schizophrenia. |
| Databáze: | OpenAIRE |
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