Pressure for Pattern-Specific Intertypic Recombination between Sabin Polioviruses: Evolutionary Implications
| Autor: | Svetlana Petrovskaya, Anatoly P. Gmyl, Eremeeva Tp, Elvira Rodionova, Elena Cherkasova, G. Y. Lipskaya, Vadim I. Agol, Ekaterina A. Korotkova, Konstantin Chumakov, Tatiana Zagorodnyaya, Olga Ivanova, Majid Laassri |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Serotype vaccine-derived polioviruses attenuation reversion virulence vaccine-induced adverse reactions Drug-Related Side Effects and Adverse Reactions viruses lcsh:QR1-502 Virulence Genome Viral Biology Genome complex mixtures Article lcsh:Microbiology Evolution Molecular 03 medical and health sciences Vaccine strain Virology Enterovirus Infections Humans Genetics Recombination Genetic RNA Poliovirus 030104 developmental biology Infectious Diseases Poliovirus Vaccine Oral Mutation Recombination Poliomyelitis |
| Zdroj: | Viruses, Vol 9, Iss 11, p 353 (2017) Viruses Viruses; Volume 9; Issue 11; Pages: 353 |
| ISSN: | 1999-4915 |
| Popis: | Complete genomic sequences of a non-redundant set of 70 recombinants between three serotypes of attenuated Sabin polioviruses as well as location (based on partial sequencing) of crossover sites of 28 additional recombinants were determined and compared with the previously published data. It is demonstrated that the genomes of Sabin viruses contain distinct strain-specific segments that are eliminated by recombination. The presumed low fitness of these segments could be linked to mutations acquired upon derivation of the vaccine strains and/or may have been present in wild-type parents of Sabin viruses. These “weak” segments contribute to the propensity of these viruses to recombine with each other and with other enteroviruses as well as determine the choice of crossover sites. The knowledge of location of such segments opens additional possibilities for the design of more genetically stable and/or more attenuated variants, i.e., candidates for new oral polio vaccines. The results also suggest that the genome of wild polioviruses, and, by generalization, of other RNA viruses, may harbor hidden low-fitness segments that can be readily eliminated only by recombination. |
| Databáze: | OpenAIRE |
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