p.Arg72Pro polymorphism of P53 and Breast Cancer Risk: A meta-analysis of case-control studies
| Autor: | Erin Neuschler, Jun Wang, Brehima Diakite, Seydou Doumbia, Guimogo Dolo, Cheick Bougadari Traore, Oumar Kassogue, Sellama Nadifi, Etienne Dembele, Mamoudou Maiga, Lifang Hou, Mamadou Keita, Robert L. Murphy, Yaya Kassogue, Bakarou Kamate |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology lcsh:Internal medicine medicine.medical_specialty lcsh:QH426-470 Genotype Breast Neoplasms Disease Polymorphism Single Nucleotide p.Arg/pro polymorphism 03 medical and health sciences Breast cancer 0302 clinical medicine Gene Frequency Risk Factors Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Allele lcsh:RC31-1245 Alleles Genetics (clinical) P53 gene business.industry Case-control study Odds ratio Publication bias medicine.disease Genotype frequency lcsh:Genetics Meta-analysis 030104 developmental biology Amino Acid Substitution Case-Control Studies 030220 oncology & carcinogenesis Female Tumor Suppressor Protein p53 business Research Article |
| Zdroj: | BMC Medical Genetics BMC Medical Genetics, Vol 21, Iss 1, Pp 1-11 (2020) |
| DOI: | 10.21203/rs.2.18400/v3 |
| Popis: | Background The effect of the p.Arg72Pro variant of the P53 gene on the risk of development ofbreast cancer remains variable in populations. However, the use ofstrategies such aspoolingage-matched controls with disease may provide a consistent meta-analysis. Our goal was to perform a meta-analysis in order to assess the association of p.Arg72Pro variant of P53 gene with the risk of breast cancer. Methods Databases such as PubMed, Genetics Medical Literature, Harvard University Library, Web of Science and Genesis Library were used to search articles. Case-control studies with age-matched on breast cancer havingevaluated the genotype frequencies of the TP53 p.Arg72Pro polymorphism were selected. The fixed and random effects (Mantel-Haenszel) were calculated using pooled odds ratio of 95% CI to determine the risk of disease. Inconsistency was calculated to determine heterogeneity among the studies. The publication bias was estimated using the funnel plot. Results Twenty-one publications with 7841 cases and 8876 controls were evaluated in this meta-analysis. Overall, our results suggested that TP53 p.Arg72Pro was associated with the risk of breast cancer for the dominant model (OR = 1.09, 95% CI = 1.02–1.16, P = 0.01) and the additive model (OR = 1.09, 95% CI = 1.01–1.17, P = 0.03), but not for the recessive model (OR = 1.07, 95% CI = 0.97–1.18, P = 0.19). According to the ethnic group analysis, Pro allele was associated with the risk of breast cancer in Caucasians for the dominant model and additive model (P = 0.02), and Africans for the recessive model and additive model (P = 0.03). Conclusions This meta-analysis found a significant association between TP53 p.Arg72Pro polymorphism and the risk of breast cancer. Individuals carrying at least one Pro allele were more likely to have breast cancer than individuals harboring the Arg allele. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|