Molecular epidemiology of COVID-19 in Oman: A molecular and surveillance study for the early transmission of COVID-19 in the country
| Autor: | Ahmed N. Al-Rawahi, Ahmed Al-Rawahi, Amina Al-Jardani, Aisha Al-Busaidi, Sajjad Asaf, Samiha Al-Kharusi, Ahmed Al-Harrasi, Majid Al-Salmani, Seif Al-Abri, Hanan Al-Kindi, Abdul Latif Khan, Intisar Al-Shukri, Adil Al-Wahaibi, Samira Al-Mahruqi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Clade Adult Male medicine.medical_specialty COVID-19 epidemiology Oman Adolescent 030106 microbiology Context (language use) Genome Viral Biology Article lcsh:Infectious and parasitic diseases 03 medical and health sciences Young Adult 0302 clinical medicine Environmental health Genetic variation Pandemic Epidemiology medicine Humans lcsh:RC109-216 030212 general & internal medicine Child Pandemics Phylogeny Molecular Epidemiology Molecular epidemiology Whole Genome Sequencing SARS-CoV-2 Outbreak COVID-19 Infant General Medicine Middle Aged Phylogenomic analysis Infectious Diseases Child Preschool Mutation (genetic algorithm) Mutation Epidemiological Monitoring Female Contact tracing |
| Zdroj: | International Journal of Infectious Diseases International Journal of Infectious Diseases, Vol 104, Iss, Pp 139-149 (2021) |
| ISSN: | 1878-3511 1201-9712 |
| Popis: | Highlights • P323L (94.7%) is the most common mutation, followed by D614G (92.6%) Spike protein mutation. • A unique mutation, I280V, was first reported in Oman and was associated with a rare lineage, B.1.113 (10.6%). • The study revealed a good agreement between genetic and epidemiological data. • Oman’s robust surveillance system was very efficient to guide the outbreak investigation processes in the country, • The study illustrates the future importance of molecular epidemiology to lead the national response to outbreaks and pandemics. Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been proven to be lethal to human health, which affects almost every corner of the world. The objectives of this study were to add context to the global data and international genomic consortiums, and to give insight into the efficiency of the contact tracing system in Oman. Methods We combined epidemiological data and whole-genome sequence data from 94 samples of SARS-CoV-2 in Oman to understand the origins, genetic variation, and transmissibility. The whole-genome size of sequence data was obtained through a customized SARS-COV-2 research panel. Amplifier methods ranged from 26 Kbp to 30 Kbp and were submitted to GISAID. Findings The study found that P323L (94.7%) is the most common mutation, followed by D614G (92.6%) Spike protein mutation. A unique mutation, I280V, was first reported in Oman and was associated with a rare lineage, B.1.113 (10.6%). In addition, the study revealed a good agreement between genetic and epidemiological data. Interpretation Oman’s robust surveillance system was very efficient in guiding the outbreak investigation processes in the country, the study illustrates the future importance of molecular epidemiology in leading the national response to outbreaks and pandemics. |
| Databáze: | OpenAIRE |
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