Dietary anthocyanin intake and age-related decline in lung function: longitudinal findings from the VA Normative Aging Study
| Autor: | Joel Schwartz, Aedin Cassidy, Amar J. Mehta, David Sparrow, Pantel S. Vokonas, Augusto A. Litonjua |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Gerontology Adult Lung Diseases Male Vital capacity Aging Vital Capacity Medicine (miscellaneous) Physiology Antioxidants Pulmonary function testing Anthocyanins Cohort Studies 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Nutritional Epidemiology and Public Health Risk Factors Forced Expiratory Volume Medicine Humans 030212 general & internal medicine Longitudinal Studies Prospective cohort study Veterans Affairs Lung Aged Veterans Aged 80 and over 030109 nutrition & dietetics Nutrition and Dietetics business.industry Confounding Anti-Inflammatory Agents Non-Steroidal Feeding Behavior clinical epidemiology lung function tests Middle Aged Nutrition Surveys anthocyanins 3. Good health Diet Quartile flavonoids diet business Cohort study Boston |
| Zdroj: | The American Journal of Clinical Nutrition Mehta, A J, Cassidy, A, Litonjua, A A, Sparrow, D, Vokonas, P & Schwartz, J 2016, ' Dietary anthocyanin intake and age-related decline in lung function: longitudinal findings from the VA Normative Aging Study ', American Journal of Clinical Nutrition, vol. 103, no. 2, pp. 542-550 . https://doi.org/10.3945/ajcn.115.121467 |
| Popis: | Background: It is unknown whether habitual intake of dietary flavonoids, known for their antioxidative and anti-inflammatory properties, affects longitudinal change in lung function. Objective: We investigated whether different flavonoid subclasses present in the habitual diet were associated with beneficial changes in lung function over time in the elderly. Design: This longitudinal analysis included 839 participants from the VA (Veterans Affairs) Normative Aging Study whose lung function [forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC)] was measured at 2 and up to 5 visits between 1992 and 2008 (n = 2623 measurements). Yearly average intake of major flavonoid subclasses (anthocyanins, flavanones, flavan-3-ols, flavonols, flavones, and polymers) was calculated from food-frequency questionnaires at each visit. We estimated adjusted differences in annual change in lung function associated with each flavonoid subclass, categorized into quartiles, in linear mixed-effects regression models after adjustment for lifestyle and dietary confounders. Results: Strong inverse associations were found between anthocyanin intake and age-related decline in lung function. Independent of dietary and nondietary risk factors, slower rates of FEV1 and FVC decline by 23.6 (95% CI: 16.6, 30.7) and 37.3 (95% CI: 27.8, 46.8) mL/y, respectively, were observed in participants in the fourth quartile of intake compared with participants in the first quartile (P-trend < 0.0001). The protective associations observed for anthocyanin intake were present in both current/former and never smokers. Compared with no or very low intakes, an intake of ≥2 servings of anthocyanin-rich blueberries/wk was associated with slower decline in FEV1 and FVC by 22.5 (95% CI: 10.8, 34.2) and 37.9 (95% CI: 22.1, 53.7) mL/y, respectively. To a lesser extent, higher flavan-3-ol intake was also associated with slower lung function decline. Conclusions: An attenuation of age-related lung function decline was associated with higher dietary anthocyanin intake in this longitudinal sample of predominantly elderly men. Further prospective studies are needed to confirm these novel associations. |
| Databáze: | OpenAIRE |
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