HIV hyperimmune globulin or intravenous immune globulin inhibits response to an HIV vaccine
| Autor: | Mary White-Scharf, Jennifer L. Maskrey, Kathelyn S. Steimer, Marie T. Jelonek, Yogesh Arora, Margaret A. Keller, Larry M. Cummins |
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| Rok vydání: | 1998 |
| Předmět: |
Globulin
Offspring animal diseases Molecular Sequence Data Biomedical Engineering chemical and pharmacologic phenomena Bioengineering HIV Antibodies HIV Envelope Protein gp120 Applied Microbiology and Biotechnology Virus Mice Immune system Drug Discovery Animals Humans Amino Acid Sequence HIV vaccine AIDS Vaccines Mice Inbred BALB C biology Process Chemistry and Technology Immunoglobulins Intravenous General Medicine biochemical phenomena metabolism and nutrition biology.organism_classification Virology Disease Models Animal Immunization Immunoglobulin G Lentivirus Immunology biology.protein bacteria Molecular Medicine Female Antibody Immunity Maternally-Acquired Biotechnology |
| Zdroj: | Biotechnology and applied biochemistry. 27(2) |
| ISSN: | 0885-4513 |
| Popis: | The murine model was developed to assess the effects of maternally transferred HIV hyperimmune globulin or human intravenous immune globulin on the immunization of the offspring at 18-21 days of age with rgp 120SF2-complete Freund's adjuvant. Either HIV hyperimmune globulin or intravenous immune globulin was administered intraperitoneally to post-partum BALB/c mice and was transferred via milk to the offspring. Both HIV hyperimmune globulin and intravenous immune globulin inhibited the offspring anti-rgp 120SF2 IgG response to the vaccine. The HIV hyperimmune globulin inhibition persisted for 28 days after immunization while the intravenous immune globulin inhibition was still present at 63 days after immunization. In addition, the intravenous immune globulin had a more generalized immunosuppressive effect, inhibiting the IgG response to both rpg 120SF2 and an additional protein antigen, hen egg-white lysozyme. Effects of maternal or exogenously administered pre-existing antibody, including control antibodies (intravenous immune globulin), on the newborn response to HIV and other vaccines must be carefully evaluated when vaccine studies proceed in newborns. |
| Databáze: | OpenAIRE |
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