Obesity and Staphylococcus aureus nasal colonization among women and men in a general population
| Autor: | Kjersti Danielsen, Tom Wilsgaard, Gunnar Skov Simonsen, Johanna U. Ericson Sollid, Anne-Sofie Furberg, Karina Standahl Olsen, Inger Thune, Maria Sangvik, Anne Elise Eggen |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Bacterial Diseases Epidemiology VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 Colony Count Microbial lcsh:Medicine medicine.disease_cause Body Mass Index Odds Ratio Clinical Epidemiology lcsh:Science Nose Aged 80 and over education.field_of_study Multidisciplinary Norway VDP::Medical disciplines: 700::Basic medical dental and veterinary science disciplines: 710::Medical microbiology: 715 Middle Aged medicine.anatomical_structure Infectious Diseases VDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803 VDP::Medisinske Fag: 700::Basale medisinske odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715 Staphylococcus aureus Medicine Female Public Health Waist Circumference Research Article Adult medicine.medical_specialty Population Infectious Disease Epidemiology Internal medicine Diabetes mellitus medicine Humans Obesity education Immunity to Infections Aged Probability Nutrition business.industry lcsh:R Immunity Odds ratio medicine.disease Immunology lcsh:Q Clinical Immunology business Body mass index |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 5, p e63716 (2013) |
| ISSN: | 1932-6203 |
| Popis: | This paper is part of Karina Olsen's doctoral thesis, available in Munin at http://hdl.handle.net/10037/5596 Background: Obesity and diabetes mellitus (DM) have been linked to increased risk of infections, and Staphylococcus aureus nasal colonization is a major risk factor for developing infections with the microbe. We therefore sought to find whether body mass index (BMI) and waist circumference (WC) could be associated with S. aureus colonization independent of DM. Methodology: S. aureus colonization was assessed by nasal swab cultures among 2,169 women and 1,709 men, aged 30–87 years, in the population-based Tromsø Staph and Skin Study in 2007–08. Height (cm), weight (kg), WC (cm), and glycated haemoglobin (HbA1c,%) were measured. Multivariable logistic regression analyses including information on DM, HbA1c, hormonal contraceptive use and other potential confounders were used. Results: In the female population, each 2.5 kg/m2 increase in BMI was associated with a 7% higher odds of S. aureus nasal colonization (P=0.01). When comparing obese and lean women aged 30–43 years, we observed that BMI $32.5 versus ,22.5 kg/m2 and WC $101 versus ,80 cm was associated with a 2.60 and 2.12 times higher odds of S. aureus colonization, respectively (95% confidence intervals 1.35–4.98 and 1.17–3.85). Among men, high WC was also associated with S. aureus nasal colonization. The associations did not change significantly when the analysis was restricted to participants without signs of pre-diabetes (HbA1c ,6.0%) among women and men, and to non-users of hormonal contraceptives among women. Conclusion: Our results support that obesity is a possible determinant for S. aureus nasal colonization independent of DM, in particular for premenopausal women. The role of obesity at different ages and by sex should be addressed in future prospective studies of S. aureus colonization. |
| Databáze: | OpenAIRE |
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