Apolipoprotein E receptor pathways in Alzheimer disease
| Autor: | Thomas E. Willnow, Vanessa Schmidt, Anne-Sophie Carlo |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Apolipoprotein E
Programmed cell death Amyloid beta-Peptides Mechanism (biology) Neurodegeneration Medicine (miscellaneous) Disease Biology medicine.disease Biochemistry Genetics and Molecular Biology (miscellaneous) LRP1 Apolipoproteins E Cholesterol Alzheimer Disease Blood-Brain Barrier medicine Humans Alzheimer's disease Receptor Neuroscience Low Density Lipoprotein Receptor-Related Protein-1 |
| Zdroj: | WIREs Systems Biology and Medicine. 6:255-270 |
| ISSN: | 1939-005X 1939-5094 |
| DOI: | 10.1002/wsbm.1262 |
| Popis: | Alzheimer disease (AD) is the most common neurodegenerative disease affecting millions of patients worldwide. According to the amyloid cascade hypothesis, the formation of neurotoxic oligomers composed of amyloid-β (Aβ) peptides is the main mechanism that causes synaptic dysfunction and, eventually, neuronal cell death in this condition. Intriguingly, apolipoprotein E (apoE), the most important genetic risk factor for sporadic AD, emerges as a key factor that contributes to many aspects of the amyloid cascade including the clearance of Aβ from brain interstitial fluid and the ability of this peptide to form neurotoxic oligomers. Central to the activity of apoE in the healthy and in the diseased brain are apoE receptors that interact with this protein to mediate its multiple cellular and systemic effects. This review describes the molecular interactions that link apoE and its cellular receptors with neuronal viability and function, and how defects in these pathways in the brain promote neurodegeneration. For further resources related to this article, please visit the WIREs website. Conflict of interest: The authors have declared no conflicts of interest for this article. |
| Databáze: | OpenAIRE |
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