Expression of Interleukin-1ß and Interleukin-8 in Oral Potentially Malignant Disorders and Carcinomas
| Autor: | Ronell Bologna-Molina, Mariana Villarroel-Dorrego, Jeaneth López-Labady |
|---|---|
| Přispěvatelé: | Lopez Labady Jeaneth, Dental School, Universidad Central de Venezuela, Caracas, Venezuela, Bologna Molina Ronell, Molecular Pathology Area, School of Dentistry, University of the Republic, Uruguay University of the Republic (UDELAR), Montevideo, Uruguay, Villarroel-Dorrego Mariana, Oral Histopathology Laboratory, Dental School, Universidad Central de Venezuela, Caracas, Venezuela |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Oral Health NEOPLASIAS DE LA BOCA Malignant transformation oral carcinoma oral lichen planus Medicine Interleukin 8 Oral mucosa Original Research Leukoplakia Inflammation IL-8 business.industry LIQUE PLANO ORAL Interleukin Oral carcinoma RK1-715 General Medicine medicine.disease IL-1b IL-8 Staining LEUCOPLASIA BUCAL stomatognathic diseases medicine.anatomical_structure IL-1β leukoplakia inflammation Dentistry Oral lichen planus Immunohistochemistry business |
| Zdroj: | Frontiers in Oral Health, Vol 2 (2021) Frontiers in Oral Health COLIBRI Universidad de la República instacron:Universidad de la República |
| ISSN: | 2673-4842 |
| Popis: | Objective: To evaluate interleukin-1ß (IL-1ß) and interleukin-8 (IL-8) epithelial expressions in potentially malignant disorders of the oral mucosa as malignant predictive markers.Study design: About 55 tissues embedded in paraffin, comprising 15 oral lichen planus (OLP) lesions, 15 leukoplakias, 15 oral squamous cell carcinomas (OSCC), and 10 samples of normal oral mucosa were included in the study. IL-1ß and 8 expressions were assessed by immunohistochemistry using antibodies antihuman IL-1ß human (sc-7884, Santa Cruz® H-153) and antihuman IL-8 (ab7747, abcam®). The number of positive cells was compared using Student's t-test. Any p-value < 0.05 was considered statistically significant.Results: Nuclear and cytoplasmatic keratinocyte staining were positive for both cytokines in all study groups. However, a statistically significant decrease was observed within all cases compared to normal mucosa, both staining for IL-1β and 8. Moreover, IL-8 showed significant differences between OLP and leukoplakia, and when compared to OSCC.Conclusions: Oral epithelial expression of IL-1β and 8 seems to decrease when the malignant transformation of the oral mucosa increases. |
| Databáze: | OpenAIRE |
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