Role of extracellular and intracellular nitric oxide in the regulation of macrophage responses
| Autor: | I. P. Khomenko, E. V. Malysheva, Eugenia B. Manukhina, I. Yu. Malyshev, L. Yu. Bakhtina, M. G. Pshennikova, S. V. Kruglov |
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| Rok vydání: | 2006 |
| Předmět: |
Lipopolysaccharides
Anti-Inflammatory Agents Apoptosis Inflammation DNA Fragmentation Nitric Oxide General Biochemistry Genetics and Molecular Biology Nitric oxide Proinflammatory cytokine Mice chemistry.chemical_compound medicine Extracellular Animals Macrophage Cells Cultured Macrophages General Medicine Macrophage Activation Cell biology Phenotype chemistry Biochemistry DNA fragmentation medicine.symptom Intracellular |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 141:404-406 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We studied the role of nitric oxide in the stress response and apoptosis. Intracellular nitric oxide potentiated the stress response. However, intracellular nitric oxide suppressed the stress response in macrophages of proinflammatory and antiinflammatory phenotypes. Intracellular nitric oxide promoted apoptosis in macrophages of the proinflammatory phenotype, but inhibited this process in cells of the antiinflammatory phenotype. Exogenous nitric oxide synthesized by macrophages protected them from lipopolysaccharide-induced apoptosis. Our results indicate that nitric oxide produces various effects on the stress response and apoptosis in macrophages, which depends on modus operandi. |
| Databáze: | OpenAIRE |
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