Renal hyperfiltration as a novel marker of all-cause mortality
| Autor: | Hyung Jin Yoon, Ho Kim, Eunsil Yoon, Jinwook Choi, Youn-Hee Lim, Minseon Park |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Kidney Glomerulus Renal function Comorbidity Severity of Illness Index Body Mass Index Sex Factors Risk Factors Internal medicine Cause of Death Republic of Korea Odds Ratio Medicine Humans Mass Screening Clinical Epidemiology Renal Insufficiency Chronic Life Style Mass screening Aged Proportional Hazards Models Retrospective Studies Anthropometry business.industry Proportional hazards model Incidence Hazard ratio Smoking Age Factors General Medicine Odds ratio Middle Aged medicine.disease Survival Analysis Surgery Quartile Nephrology Female business Body mass index Kidney disease Glomerular Filtration Rate |
| Zdroj: | Journal of the American Society of Nephrology : JASN. 26(6) |
| ISSN: | 1533-3450 |
| Popis: | Although renal hyperfiltration (RHF) or an abnormal increase in GFR has been associated with many lifestyles and clinical conditions, including diabetes, its clinical consequence is not clear. RHF is frequently considered to be the result of overestimating true GFR in subjects with muscle wasting. To evaluate the association between RHF and mortality, 43,503 adult Koreans who underwent voluntary health screening at Seoul National University Hospital between March of 1995 and May of 2006 with baseline GFR≥60 ml/min per 1.73 m(2) were followed up for mortality until December 31, 2012. GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration creatinine equation, and RHF was defined as GFR95th percentile after adjustment for age, sex, muscle mass, and history of diabetes and/or hypertension medication. Muscle mass was measured with bioimpedance analysis at baseline. During the median follow-up of 12.4 years, 1743 deaths occurred. The odds ratio of RHF in participants with the highest quartile of muscle mass was 1.31 (95% confidence interval [95% CI], 1.11 to 1.54) compared with the lowest quartile after adjusting for confounding factors, including body mass index. The hazard ratio of all-cause mortality for RHF was 1.37 (95% CI, 1.11 to 1.70) by Cox proportional hazards model with adjustment for known risk factors, including smoking. These data suggest RHF may be associated with increased all-cause mortality in an apparently healthy population. The possibility of RHF as a novel marker of all-cause mortality should be confirmed. |
| Databáze: | OpenAIRE |
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