Aging markers in human urine: A comprehensive, non‐targeted LC‐MS study
| Autor: | Haruhisa Goga, Mitsuhiro Yanagida, Takayuki Teruya |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_specialty LC‐MS Physiology Metabolite Urinary system Urine Biochemistry Genetics and Molecular Biology (miscellaneous) urinary age markers chemistry.chemical_compound Metabolomics human endocrine aging Internal medicine medicine Choline Carnitine glutathione Research Articles chemistry.chemical_classification Sugar phosphates creatinine Glutathione non‐targeted metabolomics LC-MS Amino acid Endocrinology non-targeted metabolomics Biochemistry chemistry Molecular Medicine Glutathione disulfide Quantitative analysis (chemistry) pseudouridine medicine.drug Research Article |
| Zdroj: | FASEB BioAdvances |
| ISSN: | 2573-9832 |
| Popis: | Metabolites in human biofluids document the physiological status of individuals. We conducted comprehensive, non‐targeted, non‐invasive metabolomic analysis of urine from 27 healthy human subjects, comprising 13 young adults (30 ± 3 years) and 14 seniors (76 ± 4 years). Quantitative analysis of 99 metabolites revealed 55 that displayed significant differences in abundance between the two groups. Forty‐four did not show a statistically significant relationship with age. These include 13 standard amino acids, 5 methylated, 4 acetylated, and 9 other amino acids, 6 nucleosides, nucleobases, and derivatives, 4 sugar derivatives, 5 sugar phosphates, 4 carnitines, 2 hydroxybutyrates, 1 choline, and 1 ethanolamine derivative, and glutathione disulfide. Abundances of 53 compounds decreased, while 2 (glutathione disulfide, myo‐inositol) increased in elderly people. The great majority of age‐linked markers were highly correlated with creatinine. In contrast, 44 other urinary metabolites, including urate, carnitine, hippurate, and betaine, were not age‐linked, neither declining nor increasing in elderly subjects. As metabolite profiles of urine and blood are quite different, age‐related information in urine offers additional valuable insights into aging mechanisms of endocrine system. Correlation analysis of urinary metabolites revealed distinctly inter‐related groups of compounds. |
| Databáze: | OpenAIRE |
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