Green tea polyphenols supplementation alters immunometabolism and oxidative stress in dairy cows with hyperketonemia
| Autor: | Hongyu Dai, Feng Ying, Guijie Zhang, Yi Jing, Zhang Chunhua, Song Liwen, Bao Hua, Yusheng Liang, Yan-Fen Ma, Lei Zhao, Muyang Li |
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| Rok vydání: | 2021 |
| Předmět: |
GTP'
Hyperketonemia Green tea polyphenol medicine.disease_cause Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound Animal science Food Animals Lactation Dairy cow medicine Peripartal period Original Research Article lcsh:SF1-1100 030304 developmental biology chemistry.chemical_classification 0303 health sciences biology Triglyceride Chemistry Glutathione peroxidase 0402 animal and dairy science food and beverages 04 agricultural and veterinary sciences Malondialdehyde 040201 dairy & animal science medicine.anatomical_structure biology.protein Animal Science and Zoology lcsh:Animal culture Somatic cell count Oxidative stress |
| Zdroj: | Animal Nutrition Animal Nutrition, Vol 7, Iss 1, Pp 206-215 (2021) |
| ISSN: | 2405-6545 |
| DOI: | 10.1016/j.aninu.2020.06.005 |
| Popis: | Peripartal cows often experience negative energy balance, and are therefore prone to suffering from metabolic diseases such as hyperketonemia, which causes financial losses in dairy farms. This study aimed to investigate the effect of green tea polyphenol (GTP) supplementation during the periparturient period on production performance, oxidative stress and immunometabolism in dairy cows with hyperketonemia. One hundred Holstein cows were assigned to GTP (0.2 g/kg DM; n = 50) or control (without GTP; n = 50) group based on body weight, previous milk yield, and parity on d 15 before expected parturition. Subsequently, 10 cows with hyperketonemia were selected from each group, according to blood β-hydroxybutyric acid (BHBA) concentration between 1.2 and 2.9 mmol/L from d 2 to 3 postpartum. All cows were fed a close-up diet and a lactation diet with or without GTP supply from d 15 prepartum until d 30 postpartum. Milk and blood samples were obtained from 20 cows selected with hyperketonemia on d 10, 20, and 30 postpartum. Compared with control cows, greater milk yield and lower somatic cell count were observed in GTP cows. The GTP group had lower concentrations of BHBA, free fatty acids, cholesterol, triglyceride, reactive oxygen species, malondialdehyde, and hydrogen peroxide, greater concentrations of glucose, lower activities of aspartate aminotransferase, alanine aminotransferase, and glutamyl transpeptidase, alongside greater activities of superoxide dismutase, glutathione peroxidase, and total antioxidant capacity. Additionally, GTP supplementation up-regulated concentrations of interleukin-6 and interleukin-10, but down-regulated concentrations of tumor necrosis factor-α, interleukin-1β, interleukin-2, interleukin-8, and interferon-γ in plasma. Greater concentrations of plasma immunoglobulin G were also detected in the GTP group. Overall, the data suggested that GTP supplementation from 15 d prepartum to 30 d postpartum improved the milk yield and health status in cows with hyperketonemia during early lactation. |
| Databáze: | OpenAIRE |
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