Respiratory infections in elderly people: Viral role in a resident population of elderly care centers in Lisbon, winter 2013–2014
| Autor: | Raquel Guiomar, Ana Luísa Papoila, Paulo Paixão, Maria Amália Botelho, Maria Lúcia Rodrigues, Cátia Piedade, Maria de Jesus Chasqueira, M Santos, Teresa Palmeiro, Martin D. Curran, Pedro Pechirra, Iolanda Caires, Inês Costa, Nuno Neuparth, Marta Alves |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Infecções Respiratórias 0301 basic medicine viruses medicine.disease_cause Polymerase Chain Reaction Elderly 0302 clinical medicine Homes for the Aged 030212 general & internal medicine Respiratory Tract Infections Aged 80 and over Vaccines education.field_of_study biology Respiratory tract infections musculoskeletal neural and ocular physiology Human bocavirus virus diseases General Medicine Middle Aged 3. Good health Human Parainfluenza Virus Infectious Diseases Elderly care centers Virus Diseases Aged 80 and Over Female Seasons Rhinovirus Microbiology (medical) Atypical bacteria 030106 microbiology Population macromolecular substances Article Legionella pneumophila lcsh:Infectious and parasitic diseases 03 medical and health sciences Human metapneumovirus medicine Humans lcsh:RC109-216 education Aged Respiratory viruses Portugal business.industry Respiratory infections biology.organism_classification Virology Nursing Homes respiratory tract diseases Real time PCR nervous system Enterovirus business Follow-Up Studies |
| Zdroj: | International Journal of Infectious Diseases, Vol 69, Iss, Pp 1-7 (2018) International Journal of Infectious Diseases |
| ISSN: | 1201-9712 |
| Popis: | Highlights • An etiological agent was found in 60% of the acute respiratory infections. • Human metapneumovirus showed an association with severe infection. • The importance of atypical bacteria in severe cases, in particular L. pneumophila. • The low effectiveness of the influenza vaccine. Objective The aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) in Lisbon, which housed a total of 1022 residents. Methods Nasopharyngeal swabs were collected whenever an elderly had symptoms of acute respiratory infections (ARI). PCR and RT-PCR were performed for influenza A/B, human parainfluenza virus 1–4, adenovirus, human metapneumovirus (HMPV), respiratory syncytial virus (RSV), rhinovirus, enterovirus, human coronavirus and human Bocavirus (HBoV). Array cards for atypical bacteria were also used in severe cases. Results In total, 188 episodes of ARI were reported, being rhinovirus the most frequently detected (n = 53), followed by influenza A(H3) (n = 19) and HBoV (n = 14). Severe infections were reported in 19 patients, 11 of which were fatal, Legionela pneumophila, rhinovirus, HMPV and RSV associated with these fatalities. Nine influenza strains were analyzed, all antigenically dissimilar from vaccine strain 2013/14. “Age”, “HMPV” and “Respiratory disease” showed an association with severe infection. Conclusions In this study an etiologic agent could be found in 60% of the acute respiratory episodes. These data provides information about the circulating viruses in ECC and highlights the importance of searching both viruses and atypical bacteria in severe ARI. |
| Databáze: | OpenAIRE |
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