Effects of hemoglobin on pulmonary arterial pressure and pulmonary vascular resistance in patients with chronic emphysema
| Autor: | Koichiro Tatsumi, Shigeru Momiki, Norio Kasamatsu, Masao Kinoshita, Takushi Shirai, Akira Nakamura, Ikko Hashizume, Osamu Okada, Suguru Hanzawa, Takayuki Kuriyama, Kazuyoshi Sasaki |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Hypertension Pulmonary Hemodynamics Blood Pressure Polycythemia Pulmonary Artery Hemoglobins medicine.artery medicine Humans Aged Retrospective Studies Lung business.industry Respiratory disease Hypoxia (medical) medicine.disease Pulmonary hypertension eye diseases respiratory tract diseases medicine.anatomical_structure Blood pressure Pulmonary Emphysema Anesthesia Pulmonary artery Vascular resistance Regression Analysis Female Vascular Resistance sense organs medicine.symptom business |
| Zdroj: | Respiration; international review of thoracic diseases. 67(5) |
| ISSN: | 0025-7931 |
| Popis: | Background: The increase in viscosity caused by secondary polycythemia is thought to be one of the major causes of pulmonary hypertension secondary to chronic emphysema. However, very few clinical studies considered the relation between pulmonary hypertension and polycythemia in the case of chronic obstructive pulmonary disease. Objective: The purpose of this study is to elucidate the relative contribution of an increase in hemoglobin level (Hb) to mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR). Methods: We retrospectively investigated 41 patients with chronic emphysema who had undergone a right heart catheterization. Multiple-regression analysis and F test were performed to investigate both direct effects of Hb and PaO2 as independent variables on mPAP and PVR as dependent variables. Results: Significant correlations were found between PaO2 and mPAP (or PVR), or Hb and mPAP (or PVR), indicating that both Hb and PaO2 are contributory to mPAP and PVR. The F test demonstrated that Hb and PaO2 could directly affect the level of either mPAP or PVR. Conclusions: It was concluded that Hb had a direct effect on mPAP and PVR, independently of hypoxia in patients with chronic emphysema. |
| Databáze: | OpenAIRE |
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