Angularly Substituted Octahydroindoles, Decahydroquinolines, Octahydropyrindines, and Octahydrocyclopenta[b]pyrroles by Bruylants Reaction

Autor:	Eberhard Reimann, Kurt Polborn, Christian Ettmayr
Rok vydání:	2004
Předmět:	Turn (biochemistry) Chemistry Reagent Organic chemistry General Chemistry General Medicine Nuclear magnetic resonance spectroscopy Combinatorial chemistry
Zdroj:	ChemInform. 35
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200436105
Popis:	The easily available cycloalkanoyl acetic- and propionic acid esters are transformed to the corresponding amines by standard procedures. These in turn provided an efficient access to cyclic α-aminonitriles, which were reacted with a series of Grignard reagents yielding stereoselectively the cis-configured title compounds; the scope and limitation of this route were investigated. The stereochemical assignment was achieved by X-ray crystallography and NMR spectroscopy.
Databáze:	OpenAIRE
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