Diagnostic accuracy of dual-echo (in- and opposed-phase) T1-weighted gradient recalled echo for detection and grading of hepatic iron using quantitative and visual assessment
| Autor: | Nicola Schieda, Vivek Virmani, John Ryan, Leonard Avruch, Maneesh Khanna, Subramaniyan Ramanathan |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Liver Iron Concentration medicine.medical_specialty Iron Overload Adolescent Iron Young Adult Biopsy Humans Medicine Radiology Nuclear Medicine and imaging Aged Retrospective Studies Neuroradiology Aged 80 and over medicine.diagnostic_test Echo-Planar Imaging business.industry Ultrasound Subtraction Reproducibility of Results Magnetic resonance imaging General Medicine Middle Aged medicine.disease Fatty Liver Exact test Liver Female Radiology Steatosis Nuclear medicine business Follow-Up Studies |
| Zdroj: | European Radiology. 24:1437-1445 |
| ISSN: | 1432-1084 0938-7994 |
| DOI: | 10.1007/s00330-014-3170-5 |
| Popis: | Detection and quantification of hepatic iron with dual-echo gradient recalled echo (GRE) has been proposed as a rapid alternative to other magnetic resonance imaging (MRI) techniques. Co-existing steatosis and T1 weighting are limitations. This study assesses the accuracy of routine dual-echo GRE. Between 2010 and 2013, 109 consecutive patients underwent multi-echo (ME) MRI and dual-echo GRE for quantification of hepatic iron. Liver iron concentration (LIC) was calculated from ME-MRI. Relative signal intensity (RSI) and fat signal fraction (FSF) were calculated from dual-echo GRE. Four radiologists subjectively evaluated dual-echo GRE (±subtraction). Diagnostic accuracy was compared between techniques and correlated with biopsy using Fisher’s exact test, Spearman correlation and regression. The sensitivity of visual detection of iron ranged from 48 to 55 %. Subtraction did not increase sensitivity (p |
| Databáze: | OpenAIRE |
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