Comparative study of C reactive protein and serum amyloid A protein in experimental inflammation
| Autor: | J.T. Whicher, Paul Dieppe, R E Chambers, C W Hutton |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Immunodiffusion
medicine.medical_specialty Pathology Immunology Radioimmunoassay Inflammation Reference range General Biochemistry Genetics and Molecular Biology Rheumatology Internal medicine Humans Immunology and Allergy Medicine Intradermal injection Serum amyloid A Serum Amyloid A Protein Radial immunodiffusion biology business.industry C-reactive protein Uric Acid C-Reactive Protein Endocrinology biology.protein medicine.symptom business Research Article |
| Zdroj: | Annals of the Rheumatic Diseases. 50:677-679 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.50.10.677 |
| Popis: | The responses of C reactive protein, measured by radial immunodiffusion and radioimmunoassay, and serum amyloid A protein, measured by radial immunodiffusion, were compared in eight subjects with inflammation induced experimentally by intradermal injection of monosodium urate crystals. A significant increase in serum amyloid A was noted after a lag phase of eight hours, the increase in median concentration at 48 hours being about eightfold. A parallel but less marked increase was found in C reactive protein when measured by radioimmunoassay (fourfold increase in median concentration at 48 hours) after a small but significant decrease during the lag phase. The changes in C reactive protein remained within the reference range and were not detectable by radial immunodiffusion. |
| Databáze: | OpenAIRE |
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