Long-term bone loss in insulin-dependent diabetes mellitus
| Autor: | Søren Nielsen, Paul Rødbro, J. Ditzel, B. Mathiassen |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Longitudinal study Bone density Physiology Bone remodeling Bone Density Internal medicine Diabetes mellitus Internal Medicine medicine Humans Longitudinal Studies Pathological business.industry musculoskeletal neural and ocular physiology musculoskeletal system medicine.disease humanities Confidence interval Osteopenia Bone Diseases Metabolic Diabetes Mellitus Type 1 Endocrinology Female Complication business |
| Zdroj: | Journal of Internal Medicine. 227:325-327 |
| ISSN: | 1365-2796 0954-6820 |
| DOI: | 10.1111/j.1365-2796.1990.tb00167.x |
| Popis: | The bone mineral content (BMC) in patients with insulin-dependent diabetes is reduced by 10% early in the disease, but due to a lack of long-term longitudinal studies it is unknown whether this diabetic osteopenia develops further through life. Over a time period of 11 years we examined the BMC in a group of seven adult insulin-dependent diabetics, in whom physiological and pathological factors affecting bone metabolism had been excluded; the patients were well regulated without diabetic complications. The BMC was not significantly decreased at the initial examination. The longitudinal study revealed a small but statistically significant fall in BMC, mainly in trabecular bone. The narrow (95%) confidence interval of median end value (93.3-99.0% of initial BMC) indicates that the annual decrease in BMC in such patients is of the order of 0.5%, a reduction that is probably clinically insignificant. |
| Databáze: | OpenAIRE |
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