Solid State Amorphization of β-Trehalose: A Structural Investigation Using Synchrotron Powder Diffraction and PDF Analysis
| Autor: | Pierre Bordet, William Pagnoux, Emeline Dudognon, Agnieszka Poulain, Pauline Martinetto, Jean-François willart, Erik Elkaim, Marc Descamps, Aleksei Bytchkov |
|---|---|
| Přispěvatelé: | MRS - Matériaux, Rayonnements, Structure, Institut Néel (NEEL), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Institut Laue-Langevin (ILL), ILL, Unité Matériaux et Transformations - UMR 8207 (UMET), Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Institut National de la Recherche Agronomique (INRA), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), European Synchrotron Radiation Facility (ESRF), ANR-12-BS08-0008-01,MiPhaSol,MiPhaSol, Matériaux, Rayonnements, Structure (MRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de Chimie du CNRS (INC)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL), ANR-12-BS08-0008,MI-PHA-SOL,Microstructure de solides pharmaceutiques stressés(2012), Matériaux, Rayonnements, Structure (NEEL - MRS), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
High energy Materials science Solid-state Glycosidic bond 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Trehalose Amorphous phase 0104 chemical sciences Amorphous solid Synchrotron powder diffraction chemistry.chemical_compound Crystallography chemistry Molecule General Materials Science [PHYS.COND.CM-SCE]Physics [physics]/Condensed Matter [cond-mat]/Strongly Correlated Electrons [cond-mat.str-el] 0210 nano-technology |
| Zdroj: | Crystal Growth and Design Crystal Growth and Design, American Chemical Society, 2016, 16 (8), pp.4547-4558. ⟨10.1021/acs.cgd.6b00660⟩ Crystal Growth & Design Crystal Growth & Design, American Chemical Society, 2016, 16 (8), pp.4547-4558. ⟨10.1021/acs.cgd.6b00660⟩ Crystal Growth & Design, 2016, 16 (8), pp.4547-4558. ⟨10.1021/acs.cgd.6b00660⟩ |
| ISSN: | 1528-7483 1528-7505 |
| DOI: | 10.1021/acs.cgd.6b00660⟩ |
| Popis: | International audience; We have investigated the amorphization of β-trehalose by high energy milling using in situ and ex situ synchrotron powder diffraction and PDF analysis. From this analysis we show that amorphization takes place through a two-phase process involving an amorphous and a long-range ordered phase. The proportion and coherent domain size of the latter rapidly decrease with milling time until the whole sample appears amorphized. The PDF describing the local structure of the amorphous phase after two hours of milling is very close to that of a sample quenched from the liquid, and seems to continue to evolve for longer milling times. Their differences with the PDF expected for a rigid THL molecule confirm the existence of a conformational disorder of the torsion angles from the glycosidic linkage between the two cycles forming the molecule. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|