Selective vulnerability of brainstem and cervical spinal cord regions in people with non-progressive multiple sclerosis of Black or African American and European ancestry
| Autor: | Darin T Okuda, Thomas Stanley, Morgan McCreary, Alexander Smith, Andrew Wilson, Marco C Pinho, Fang F Yu, Thibo Billiet, Wim Van Hecke, Annemie Ribbens, Burcu Zeydan, Orhun Kantarci, Xiaohu Guo, Tatum M Moog |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Multiple Sclerosis Journal. 29:691-701 |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/13524585221139575 |
| Popis: | Background: We evaluated imaging features suggestive of neurodegeneration within the brainstem and upper cervical spinal cord (UCSC) in non-progressive multiple sclerosis (MS). Methods: Standardized 3-Tesla three-dimensional brain magnetic resonance imaging (MRI) studies were prospectively acquired. Rates of change in volume, surface texture, curvature were quantified at the pons and medulla-UCSC. Whole and regional brain volumes and T2-weighted lesion volumes were also quantified. Independent regression models were constructed to evaluate differences between those of Black or African ancestry (B/AA) and European ancestry (EA) with non-progressive MS. Results: 209 people with MS (pwMS) having at least two MRI studies, 29% possessing 3–6 timepoints, resulted in 487 scans for analysis. Median follow-up time between MRI timepoints was 1.33 (25th–75th percentile: 0.51–1.98) years. Of 183 non-progressive pwMS, 88 and 95 self-reported being B/AA and EA, respectively. Non-progressive pwMS demonstrated greater rates of decline in pontine volume ( p Conclusions: Selectively vulnerable regions within the brainstem-UCSC may allow for more personalized approaches to disease surveillance and management. |
| Databáze: | OpenAIRE |
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