Selective Three-Component 1,2-Aminoalkoxylation of 1-Aryl-1,3-dienes by Dual Photoredox and Copper Catalysis

Autor:	Ya-Li Wu, Min Jiang, Li Rao, Ying Cheng, Wen-Jing Xiao, Jia-Rong Chen
Rok vydání:	2022
Předmět:	Oxygen Alcohols Organic Chemistry Salts Polyenes Physical and Theoretical Chemistry Biochemistry Catalysis Copper
Zdroj:	Organic Letters. 24:7470-7475
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.2c03124
Popis:	A three-component 1,2-aminooxygenation reaction of 1,3-dienes by dual photoredox and copper catalysis is described. This protocol usesiN/i-aminopyridinium salts as N-centered radical precursors and nucleophilic alcohols as oxygen sources, providing modular and practical access to 1,2-aminoalkoxylation products with good yields and regioselectivity. Preliminary mechanistic studies support the radical property of the reaction and the involvement of N-centered radical intermediates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9a00284f2b9b8a243d9d1fc5d37dbb https://doi.org/10.1021/acs.orglett.2c03124 Zobrazit plný text záznamu