The impact of folate and vitamin B12 status on cognitive function and brain atrophy in healthy elderly and demented Austrians, a retrospective cohort study
| Autor: | Markus Herrmann, Reinhold Schmidt, Edith Hofer, Gerhard Ransmayr, Jasmin Rabensteiner, Peter Dal-Bianco, Eva Fritz-Petrin, Thomas Benke, Günter Fauler |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Aging medicine.medical_specialty Disease folate Cohort Studies Atrophy Cognition Folic Acid Alzheimer Disease Internal medicine medicine Dementia Humans Vitamin B12 cognitive function Aged Retrospective Studies Aged 80 and over business.industry Brain Retrospective cohort study Cell Biology vitamin B12 homocysteine Middle Aged medicine.disease Cognitive test Vitamin B 12 Austria Brain size Female business Research Paper dementia |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Background Dementia, and in particular Alzheimer's disease (AD), is a debilitating progressive disease with high prevalence in our society. Vitamin B12 and folate deficiency are potential modifiable risk factors. However, previous studies reported inconsistent results. Results The average concentrations of all biochemical markers were within the respective reference ranges. Cross-sectional and longitudinal analyses did not reveal significant associations between biochemical markers and cognitive function, global or regional brain volume, cortical thickness or cortical surface area, neither in controls nor in AD patients. Conclusions Variations of direct and indirect markers of B12 and folate status are not associated with cognitive dysfunction and brain atrophy. Methods This retrospective study explored the association between biochemical markers of B12 and folate status, cognitive function and MRI-based brain atrophy in cognitive normal elderly (controls) and AD patients. Folate, total and active vitamin B12 and MMA were measured in blood samples from 378 controls and 217 AD patients. Neuropsychiatric tests capturing memory, executive function and visuopractical skills were performed in all participants. Brain atrophy was assessed by MRI in 155 controls and 217 AD patients. In a subset of participants cognitive testing (n=234) and MRI (n=182) was repeated after an average median between 1.25 and 6.25 years. |
| Databáze: | OpenAIRE |
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