Self-initiated physical activity is associated with high sensitivity C-reactive protein: A longitudinal study in 5,030 adults

Autor: P. Babu Balagopal, Gabriel Grizzo Cucato, Raul D. Santos, Rômulo Araújo Fernandes, Raphael Mendes Ritti-Dias, Raquel D. Conceição, Márcio Sommer Bittencourt
Přispěvatelé: Universidade Estadual Paulista (Unesp), Universidade Nove de Julho, Nemours Children's Specialty Care and Mayo Clinic College of Medicine, Hospital Israelita Albert Einstein, Universidade de São Paulo (USP), Faculdade Israelita de Ciências da Saúde Albert Einstein
Rok vydání: 2018
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 0021-9150
Popis: Made available in DSpace on 2018-12-11T16:52:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-01 Background and aims: Structured regular exercise programs decrease high-sensitivity C-reactive protein (hsCRP), a marker of low-grade inflammation in adults. Longitudinal effects of self-initiated physical activity levels (PAL) on hsCRP are less clear. This study evaluated the association of longitudinal changes in hsCRP in relation to modifications in PAL, over time, in a large sample of adults. Methods: Participants included 5030 adults, 4045 (80%) males, undergoing routine health screening examinations. Elevated level of hsCRP was defined as ≥3 mg/L. Self-reported PAL, height, weight, blood pressure and blood samples were collected at baseline and after a median of 2.9 years (P25th 1.97 and P75th 4.37 yrs). Participants were stratified according to their PAL at baseline and follow-up as: i) persistently physically inactive; ii) became physically inactive; iii) became physically active; iv) persistently physically active (active both at baseline and follow-up). Results: Persistently physically active participants had lower odds of having higher hsCRP (OR = 0.35 [95% CI: 0.25 to 0.48]). The maintenance of high PAL was associated with lower hsCRP in both sexes (men: OR = 0.44 [0.30 to 0.65] and women: OR = 0.35 [0.16 to 0.76]). Participants with overweight/obesity (OR = 0.43 [95% CI: 0.29 to 0.63]) and smokers (OR = 0.123 [95% CI: 0.03 to 0.60]) who were persistently active had lower odds of having higher hsCRP compared to physically inactive peers. Conclusions: Self-initiated PAL was longitudinally associated with hsCRP in adults. The data suggest that the initiation or maintenance of PA attenuates the low-grade inflammatory state, independent of sex, body weight and smoking status. Sao Paulo State University (UNESP) Universidade Nove de Julho Nemours Children's Specialty Care and Mayo Clinic College of Medicine Hospital Israelita Albert Einstein Lipid Clinic Heart Institute (InCor) University of São Paulo Faculdade Israelita de Ciências da Saúde Albert Einstein Sao Paulo State University (UNESP)
Databáze: OpenAIRE
Externí odkaz: