Ophthalmic features of HIV associated cryptococcal meningitis in Malawian Adults: an observational study
| Autor: | Robert S. Heyderman, Thomas S. Harrison, Jayne Ellis, Katherine M Gaskell, Jack Gormley, Patty Mopamboli, Newton Kalata, David G. Lalloo, Ian J. C. MacCormick, Philip I. Burgess, Mary Peirse, Ebbie Gondwe, Christine A. Kiire, Chatonda A. Manda, Síle F. Molloy |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry Human immunodeficiency virus (HIV) Medicine (miscellaneous) Retinal medicine.disease medicine.disease_cause Gastroenterology General Biochemistry Genetics and Molecular Biology 3. Good health 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Disease severity Internal medicine 030221 ophthalmology & optometry medicine Optic disc swelling Observational study Abnormality Cryptococcal meningitis business 030217 neurology & neurosurgery Retinopathy |
| Zdroj: | Wellcome Open Research |
| Popis: | Background: Cryptococcal meningitis (CM) is the commonest neurological complication in patients with advanced HIV. Visual disturbance is a frequent presenting symptom. Papilloedema is commonly reported but other ophthalmic findings are not well described. Methods: We performed an observational study comparing severely immunocompromised HIV-infected patients with and without CM to determine the nature and prevalence of retinal pathology attributable to CM. 70 adult patients were enrolled in Blantyre Malawi, 35 with CM and 35 HIV-infected patients without CM. Results: 79% (19/24) of CM patients examined on day one had evidence of retinal abnormalities compared to 17% (6/35) of HIV-infected controls (p Conclusions: Whether the presence of CM retinopathy could be used as a marker of disease severity warrants further investigation. The observed ophthalmic findings provide a descriptive framework for CM retinopathy to be utilised in future CM studies. Trial registration: ISRCTN (ISRCTN45035509) 19/06/2012. |
| Databáze: | OpenAIRE |
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