Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project
| Autor: | Julie E. Buring, Rashmi Sinha, Julie R. Palmer, Kim Robien, Marcia L. Stefanick, Jill Koshiol, Edward Giovannucci, Andrew T. Chan, Mark P. Purdue, Jean Wactawski-Wende, Katherine A. McGlynn, Jenny N. Poynter, Gabriella Andreotti, Dawn Q. Chong, Catherine Schairer, Michele M. Doody, Linda M. Liao, I-Min Lee, Lynn Rosenberg, Laura Beane-Freeman, Howard D. Sesso, Susan M. Gapstur, Martha S. Linet, Meir J. Stampfer, John Michael Gaziano, Jessica L. Petrick, Peter T. Campbell, Anne Zeleniuch-Jacquotte, Xuehong Zhang, Jake E. Thistle, Barry I. Graubard, Neal D. Freedman |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Carcinoma Hepatocellular Alcohol Drinking medicine.medical_treatment Gastroenterology Article Cholangiocarcinoma Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Tobacco medicine Humans Prospective cohort study Aged Aged 80 and over business.industry Liver Neoplasms Smoking Hazard ratio Case-control study Middle Aged medicine.disease Confidence interval 3. Good health Bile Ducts Intrahepatic Bile Duct Neoplasms Oncology Case-Control Studies 030220 oncology & carcinogenesis Hepatocellular carcinoma Smoking cessation Female 030211 gastroenterology & hepatology Liver cancer business Cohort study |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background While tobacco and alcohol are established risk factors for hepatocellular carcinoma (HCC), the most common type of primary liver cancer, it is unknown whether they also increase the risk of intrahepatic cholangiocarcinoma (ICC). Thus, we examined the association between tobacco and alcohol use by primary liver cancer type. Methods The Liver Cancer Pooling Project is a consortium of 14 US-based prospective cohort studies that includes data from 1,518,741 individuals (HCC n = 1423, ICC n = 410). Multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (CI) were estimated using proportional hazards regression. Results Current smokers at baseline had an increased risk of HCC (hazard ratio (HR) = 1.86, 95% confidence interval (CI): 1.57–2.20) and ICC (HR = 1.47, 95% CI: 1.07–2.02). Among individuals who quit smoking >30 years ago, HCC risk was almost equivalent to never smokers (HR = 1.09, 95% CI: 0.74–1.61). Compared to non-drinkers, heavy alcohol consumption was associated with an 87% increased HCC risk (HR≥7 drinks/day = 1.87, 95% CI: 1.41–2.47) and a 68% increased ICC risk (HR≥5 drinks/day = 1.68, 95% CI: 0.99–2.86). However, light-to-moderate alcohol consumption of 0–0.5– |
| Databáze: | OpenAIRE |
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