Lowered sensitivity of bitter taste receptors to β-glucosides in bamboo lemurs: an instance of parallel and adaptive functional decline in TAS2R16?
| Autor: | Fabrizio Fierro, Masha Y. Niv, M. Elise Lauterbur, Anthony J. Tosi, Akihiro Itoigawa, Hiroo Imai, Morgan E. Chaney, Takashi Hayakawa |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Most recent common ancestor Bamboo Evolution Lemur Zoology Lemur catta 010603 evolutionary biology 01 natural sciences General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Species Specificity biology.animal Animals bitter taste receptor Functional decline Receptor Research Articles 030304 developmental biology General Environmental Science Prolemur simus glucosides cyanide 0303 health sciences General Immunology and Microbiology biology molecular adaptation Lemuridae homoplasy General Medicine biology.organism_classification Taste General Agricultural and Biological Sciences Bitter taste receptors |
| Zdroj: | Proceedings of the Royal Society B: Biological Sciences |
| ISSN: | 1471-2954 0962-8452 |
| DOI: | 10.1098/rspb.2021.0346 |
| Popis: | Bitter taste facilitates the detection of potentially harmful substances and is perceived via bitter taste receptors (TAS2Rs) expressed on the tongue and oral cavity in vertebrates. In primates, TAS2R16 specifically recognizes β-glucosides, which are important in cyanogenic plants' use of cyanide as a feeding deterrent. In this study, we performed cell-based functional assays for investigating the sensitivity of TAS2R16 to β-glucosides in three species of bamboo lemurs ( Prolemur simus, Hapalemur aureus and H. griseus ), which primarily consume high-cyanide bamboo. TAS2R16 receptors from bamboo lemurs had lower sensitivity to β-glucosides, including cyanogenic glucosides, than that of the closely related ring-tailed lemur ( Lemur catta ). Ancestral reconstructions of TAS2R16 for the bamboo-lemur last common ancestor (LCA) and that of the Hapalemur LCA showed an intermediate sensitivity to β-glucosides between that of the ring-tailed lemurs and bamboo lemurs. Mutagenetic analyses revealed that P. simus and H. griseus had separate species - specific substitutions that led to reduced sensitivity. These results indicate that low sensitivity to β-glucosides at the cellular level—a potentially adaptive trait for feeding on cyanogenic bamboo—evolved independently after the Prolemur – Hapalemur split in each species. |
| Databáze: | OpenAIRE |
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