Allicin Reversed the Process of Frailty in Aging Male Fischer 344 Rats With Osteoporosis
| Autor: | Yaping Xu, Jianwei Shen, Yajun Yang, Meigui You, Dongtao Wang, Yang Liu, Lin Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine THE JOURNAL OF GERONTOLOGY: Biological Sciences Aging Senile osteoporosis Osteoporosis Physiology Antiosteoporosis effect Bone resorption Bone remodeling AcademicSubjects/MED00280 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Bone Density Oral administration medicine Animals Disulfides Pharmaceutical intervention Bone mineral Frailty index Frailty Allicin business.industry Aging male Sulfinic Acids medicine.disease Rats Inbred F344 Rats 030104 developmental biology chemistry AcademicSubjects/SCI00960 Bones and Osteoporosis Bone Remodeling Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glz205 |
| Popis: | The research and development of pharmaceutical intervention is insufficient for the frail older adults, especially in preclinical stage for the frail individuals with osteoporosis. Garlic exerts an antiosteoporotic effect and its vital component allicin could protect organisms against aging. The present study aimed to investigate the effect of long-term intragastric administration of allicin (low dose of 4 mg·kg−1·d−1; middle dose of 8 mg·kg−1·d−1; high dose of 16 mg·kg−1·d−1) on frailty with osteoporosis in aging male Fischer 344 rats. Frailty was assessed with a 27-item frailty index based on quantifying health-related deficits in adult male rats varied from 13 to 21 months and in control rats from 6 to 9 months. Osteoporosis was appraised by bone mineral density detected by dual-energy X-ray absorptiometry, biomechanical properties measured by a three-point bending test, and bone metabolic analysis using ELISA. Allicin could attenuate frailty index scores by reducing the accumulation of health deficits in aging male Fischer 344 rats. Meanwhile, allicin could protect against senile osteoporosis, and the underlying mechanism may involve in increasing low bone turnover through elevation of both bone formation and bone resorption, and subsequently lead to increase of bone mineral density, contributing to reversing deleterious bone biomechanical features associated with aging. The present study reveals firstly that long-term oral administration with allicin attenuated frailty with osteoporosis during the process of aging, which provides a preclinical evidence for intervention of frailty. |
| Databáze: | OpenAIRE |
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