Is mitochondrial DNA quantitation in blastocyst trophectoderm cells predictive of developmental competence and outcome in clinical IVF?
| Autor: | Manuel Viotti, Frank L. Barnes, Christo Zouves, Andrea R. Victor |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Mitochondrial DNA medicine.medical_specialty Reproductive medicine Embryonic Development Review Fertilization in Vitro Biology Bioinformatics DNA Mitochondrial Competence (law) 03 medical and health sciences 0302 clinical medicine Pregnancy Genetics medicine Humans Embryo Implantation Blastocyst Genetics (clinical) 030219 obstetrics & reproductive medicine Obstetrics and Gynecology Embryo General Medicine Human genetics Embryo transfer 030104 developmental biology medicine.anatomical_structure Reproductive Medicine embryonic structures Biomarker (medicine) Female Developmental Biology |
| Zdroj: | Journal of Assisted Reproduction and Genetics. 34:1581-1585 |
| ISSN: | 1573-7330 1058-0468 |
| Popis: | Behind every successful IVF embryo transfer, there is a great game of chance. Methods seeking to tilt the balance and increase the likelihood of implantation have been proposed and implemented with varying results, including embryo morphology, FISH-PGS, comprehensive chromosomal screening (CCS), morphokinetics, endometrial receptivity testing. It has been suggested that mitochondrial DNA (mtDNA) copy number could serve as a biomarker for embryo viability, but this concept was recently challenged. The world of IVF is left with unanswered questions: Why are there discrepancies in the reports? Should mtDNA copy number be considered to rank embryos for transfer? And in a broader sense, how well must a technique be validated before its implementation in the IVF clinic? Here, we explore these questions attempting to piece together the published data and suggest future directions to help unravel the subject matter. |
| Databáze: | OpenAIRE |
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