Cellulose nanocrystals as support nanomaterials for dual droplet-based freeform 3D printing
| Autor: | Keonwook Nam, Young Hoon Roh, Kyungjik Yang, Young-Min Kim, Hyung Sun Yoon |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Fabrication Shear thinning Polymers and Plastics Tissue Engineering business.industry Alginates Organic Chemistry Biomaterial 3D printing Hydrogels Nanomaterials Rheology Chemical engineering Self-healing hydrogels Printing Three-Dimensional Materials Chemistry business Cellulose Layer (electronics) |
| Zdroj: | Carbohydrate polymers. 272 |
| ISSN: | 1879-1344 |
| Popis: | The selection of sacrificial support materials is important in the fabrication of complex freeform structures. In this study, a dual droplet-based, freeform 3D printing method for pseudoplastic alginate biomaterial inks was developed using Bingham plastic cellulose nanocrystals (CNCs) as support nanomaterials. CNCs-CaCl2 mixture compositions and alginate concentrations were varied to enhance printability with rheological properties of shape fidelity and structural stability. The mixtures supported the shape of alginate and allowed CaCl2 diffusion-based cross-linking during 3D printing. The hydrogels showed rheological and physicochemical properties similar to those of pure alginate hydrogel, as CNCs were removed during post-printing processing. BSA-loaded multi-layered spheres, freeform 3D-printed for oral protein drug delivery, protected BSA in the gastric environment and provided controlled and sustained release of BSA into the intestinal environment as layer width and alginate concentration increased. This method can facilitate freeform 3D printing of diverse pseudoplastic biomaterial inks for biomedical applications. |
| Databáze: | OpenAIRE |
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