Cardiac allografts with ischemic time over 300 minutes
| Autor: | L. Friend, H. Laks, A. Sykes, C. Burch, Daniel Marelli, E. Houston, Feng-Chun Tsai, A. Vellaca, Jessica Bresson, Jon A. Kobashigawa |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pulmonary and Respiratory Medicine
Transplantation medicine.medical_specialty business.industry Ischemic time Washout Hemodynamics law.invention surgical procedures operative law Internal medicine Cardiology medicine Cardiopulmonary bypass Weaning Surgery Viaspan Cardiology and Cardiovascular Medicine business High group Coronary sinus |
| Zdroj: | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 20(2) |
| ISSN: | 1557-3117 |
| Popis: | ing a cardiopulmonary bypass (CPB). Hemodynamics of the transplanted graft was assessed by comparing recovery rates (%) from donor hearts 2hr after weaning from CPB. Endothelin-1 (ET-1) levels were measured in the blood obtained from the coronary sinus 30 min after reperfusion. Transplanted grafts were then harvested for histological study. Results: CO, LVP and LVdP/dt were significantly (p , 0.05) better in the high group than in the low group (table). There were no significant differences in the ET-1 levels between the groups. Transmission electron microscopic findings revealed that degeneration of mitochondria was less extensive in the high group than in the low group. There was no obvious ultrastructural damage of the endothelial cells in either group. Conclusion: When using UW solution in heart procurement, a higher pressure is optimal for complete washout of blood components and distribution of the solution. |
| Databáze: | OpenAIRE |
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