Enzymology and significance of protein histidine methylation
| Autor: | Magnus E. Jakobsson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
PTM
post-translational modification post-translational modification (PTM) SILAC stable isotope labeling by amino acids in cell culture Systems biology 7BS seven beta strand Regulator SET (Su(var)3-9 Enhancer-of-zeste Trithorax) Computational biology Biology Proteomics 3MeH N3-methylhistidine Biochemistry PHMT protein histidine methyltransferase proteomics MT methyltransferase Stable isotope labeling by amino acids in cell culture 1MeH N1-methylhistidine Protein methylation Epigenetics protein methylation Molecular Biology Hme histidine methylation Hpm1 histidine protein methyltransferase 1 epigenetics JBC Reviews systems biology Cell Biology Methylation histidine enzyme Function (biology) |
| Zdroj: | The Journal of Biological Chemistry |
| ISSN: | 1083-351X 0021-9258 |
| Popis: | Cells synthesize proteins using 20 standard amino acids and expand their biochemical repertoire through intricate enzyme-mediated post-translational modifications (PTMs). PTMs can either be static and represent protein editing events or be dynamically regulated as a part of a cellular response to specific stimuli. Protein histidine methylation (Hme) was an elusive PTM for over 5 decades and has only recently attracted considerable attention through discoveries concerning its enzymology, extent, and function. Here, we review the status of the Hme field and discuss the implications of Hme in physiological and cellular processes. We also review the experimental toolbox for analysis of Hme and discuss the strengths and weaknesses of different experimental approaches. The findings discussed in this review demonstrate that Hme is widespread across cells and tissues and functionally regulates key cellular processes such as cytoskeletal dynamics and protein translation. Collectively, the findings discussed here showcase Hme as a regulator of key cellular functions and highlight the regulation of this modification as an emerging field of biological research. |
| Databáze: | OpenAIRE |
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