Chronic gastric ulcers are not predisposed to tumor formation when exposed to a low dose of carcinogen
| Autor: | K.F. Siu, John Wong, William I. Wei |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Pathology Methylnitronitrosoguanidine Gastroenterology Gastric Acid Stomach Neoplasms Internal medicine Gastrins medicine Animals Gastric tumor Stomach Ulcer Carcinogen business.industry Stomach Low dose Chronic gastric ulcer Intestinal metaplasia Liter Rats Inbred Strains medicine.disease digestive system diseases Tumor formation Rats medicine.anatomical_structure Liver Carcinogens Surgery Female business |
| Zdroj: | The Journal of surgical research. 41(1) |
| ISSN: | 0022-4804 |
| Popis: | The purpose of this experiment was to determine whether chronic gastric ulcers in the rat are predisposed to tumor formation when exposed to a usually noncarcinogenic dose of the carcinogen, N -Methyl- N′ -nitro- N -nitrosoguanidine (MNNG). Two groups of rats were prepared; one subjected to a standard ulcer-producing operation, the other as control. Both groups were given oral MNNG (100 mg/liter as drinking water) for 12 weeks, the carcinogen was then stopped and replaced with tap water, and the experiment terminated at 52 weeks. Results showed that a low dose of carcinogen (200 mg) did not induce tumor formation in any of the normal rats. In the presence of a chronic gastric ulcer, only intestinal metaplasia and hyperplastic glandular nodules were observed, but there were no gastric tumors. It is concluded that the presence of a chronic gastric ulcer did not increase the likelihood of gastric tumor formation in rats treated with a noncarcinogenic dose of the carcinogen MNNG. |
| Databáze: | OpenAIRE |
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