Plasma Levels of Amyloid-β Peptides and Tau Protein in Mexican Patients with Alzheimer’s Disease
| Autor: | Sandra Orozco-Suárez, Tzayaka Castillo-Mendieta, Aldo Javier Rodríguez-Sánchez de Tagle, Christian Guerra-Araiza, Rodolfo Pinto-Almazán, Julia J. Segura-Uribe, Elizabeth Ruiz-Sánchez, Victoria Campos-Peña, Yoaly Arana-Lechuga, Ana Luisa Sosa |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Tau protein tau Proteins Disease Gastroenterology chemistry.chemical_compound Alzheimer Disease Internal medicine mental disorders medicine Humans Dementia Cognitive decline Mexico Aged Aged 80 and over Amyloid beta-Peptides Triglyceride biology business.industry Cholesterol General Neuroscience General Medicine Plasma levels Middle Aged medicine.disease Amyloid β peptide Psychiatry and Mental health Clinical Psychology chemistry biology.protein Female Geriatrics and Gerontology business Biomarkers |
| Zdroj: | Journal of Alzheimer's Disease. 82:S271-S281 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: Alzheimer’s disease (AD) causes memory deficit and alterations in other cognitive functions, mainly in adults over 60 years of age. As the diagnosis confirmation is performed by a postmortem neuropathological examination of the brain, this disease can be confused with other types of dementia at early stages. About 860,000 Mexicans are affected by dementia, most of them with insufficient access to adequate comprehensive health care services. Plasma biomarkers could be a rapid option for early diagnosis of the disease. Objective: This study aimed to analyze some plasma biomarkers (amyloid-β, tau, and lipids) in Mexican AD patients and control subjects with no associated neurodegenerative diseases. Methods: Plasma amyloid-β peptides (Aβ40 and Aβ42), total and phosphorylated tau protein (T-tau and P-tau), and cholesterol and triglyceride levels were quantified by enzyme-linked immunosorbent assay in AD patients and control subjects. Results: In Mexican AD patients, we found significantly lower levels of Aβ42 (p |
| Databáze: | OpenAIRE |
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