Transgenic models for investigating the nervous system: Currently available neurofluorescent reporters and potential neuronal markers
| Autor: | Charles Q. Yu, Sneha Bontu, Neeraj Chawla, Samuel M. Santosa, Sebastian Giakas, Dimitri T. Azar, Arjun Prakash Tambe, Arnold Nadel, Michael Yamakawa, Mark I. Rosenblatt, Kyu-Yeon Han, Kai Guo, Evguenia Ivakhnitskaia, Matthew del Pino, Jin-Hong Chang, Maria S. Cortina |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nervous system Future studies Neurogenesis Transgene Biophysics Mice Transgenic Biology Nervous System Biochemistry Article Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Nervous System Physiological Phenomena Molecular Biology Neurons Cell specific Brain 030104 developmental biology medicine.anatomical_structure Cytoarchitecture Peripheral nervous system Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Biochim Biophys Acta Gen Subj |
| ISSN: | 0304-4165 |
| DOI: | 10.1016/j.bbagen.2020.129595 |
| Popis: | Recombinant DNA technologies have enabled the development of transgenic animal models for use in studying a myriad of diseases and biological states. By placing fluorescent reporters under the direct regulation of the promoter region of specific marker proteins, these models can localize and characterize very specific cell types. One important application of transgenic species is the study of the cytoarchitecture of the nervous system. Neurofluorescent reporters can be used to study the structural patterns of nerves in the central or peripheral nervous system in vivo, as well as phenomena involving embryologic or adult neurogenesis, injury, degeneration, and recovery. Furthermore, crucial molecular factors can also be screened via the transgenic approach, which may eventually play a major role in the development of therapeutic strategies against diseases like Alzheimer's or Parkinson's. This review describes currently available reporters and their uses in the literature as well as potential neural markers that can be leveraged to create additional, robust transgenic models for future studies. |
| Databáze: | OpenAIRE |
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