The angiotensin type 2 receptor and the kidney
| Autor: | U. Muscha Steckelings, Robson A.S. Santos, Thomas Unger, Antonio A B Peluso |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Angiotensin receptor Receptor expression BLOOD-PRESSURE 030204 cardiovascular system & hematology Pharmacology Kidney Tubules Proximal Angiotensin 0302 clinical medicine AT2-receptor Obesity/metabolism Diabetic Nephropathies COMPOUND 21 Kidney biology Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors Sodium-Hydrogen Exchanger 3 II RECEPTORS Receptor Angiotensin Type 2/agonists FACTOR-KAPPA-B medicine.anatomical_structure Nephrology AT2 RECEPTOR nephropathy Sodium-Potassium-Exchanging ATPase RENAL-FUNCTION Natriuresis AT(2) RECEPTOR renal physiology Receptor Angiotensin Type 2 Nephropathy OBESE ZUCKER RATS DIABETIC-NEPHROPATHY 03 medical and health sciences Sex Factors Internal Medicine medicine Animals Humans Obesity SPONTANEOUSLY HYPERTENSIVE-RATS Sodium-Hydrogen Exchanger 3/antagonists & inhibitors Angiotensin II receptor type 1 Kidney Tubules Proximal/metabolism business.industry Angiotensin-converting enzyme angiotensin medicine.disease Angiotensin II Renal physiology Diuresis 030104 developmental biology biology.protein Diabetic Nephropathies/drug therapy business Kidney disease |
| Zdroj: | Peluso, A A B, Santos, R A S, Unger, T H & Steckelings, U M 2017, ' The angiotensin type 2 receptor and the kidney ', Current Opinion in Nephrology & Hypertension, vol. 26, no. 1, pp. 36-42 . https://doi.org/10.1097/MNH.0000000000000289 |
| ISSN: | 1473-6543 |
| Popis: | PURPOSE OF REVIEW: Angiotensin II is a main regulator of kidney function. Renal actions mediated by the angiotensin AT1 receptor have been well known for many years. In contrast, several details of angiotensin AT2 receptor actions in kidney physiology and pathophysiology were only described very recently. These findings are reviewed in this article.RECENT FINDINGS: Regarding the role of the angiotensin AT2 receptor in kidney physiology, a major recent finding was that the AT2 receptor-mediated inhibition of Na-H exchanger-3 and Na/K-ATPase in the renal proximal tubules is caused by internalisation of these transporters, thus reducing reabsorption and increasing natriuresis/diuresis. Regarding renal pathology, several studies demonstrated an attenuation of renal injury caused by diabetes or by obesity with or without high-salt diet through anti-inflammatory, antifibrotic, and antioxidative mechanisms. Generally, AT2 receptor expression seems increased and AT2 receptor-mediated effects stronger in female and obese animals.SUMMARY: The recent findings about the role of the angiotensin AT2 receptor in renal health and disease strongly suggest that pharmacological targeting of this receptor with selective agonists is a promising therapeutic strategy for inducing diuresis/natriuresis (also additive to established diuretics) and for the treatment of diabetic nephropathy or kidney disease of other pathogenesis. |
| Databáze: | OpenAIRE |
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