Preparation of pH-sensitive Anionic Liposomes Designed for Drug Delivery System (DDS) Application
| Autor: | Norio Tobori, Makoto Yuasa, Takeshi Kondo, Taku Ogura, Hikaru Akaboshi, Asami Aoki, Tatsuo Aikawa |
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| Rok vydání: | 2015 |
| Předmět: |
Anions
Membrane Fluidity General Chemical Engineering Sodium Polysorbates chemistry.chemical_element Phosphatidylserines chemistry.chemical_compound Drug Delivery Systems Drug Stability Membrane fluidity Sorbitan monostearate Liposome Chromatography Molecular Structure Chemistry Bilayer General Medicine General Chemistry Hydrogen-Ion Concentration Membrane Chemical engineering Drug Design Liposomes Dispersion stability Drug delivery Dimyristoylphosphatidylcholine Oleic Acid |
| Zdroj: | Journal of Oleo Science. 64:233-242 |
| ISSN: | 1347-3352 1345-8957 |
| DOI: | 10.5650/jos.ess14157 |
| Popis: | We prepared pH-sensitive anionic liposomes composed solely of anionic bilayer membrane components that were designed to promote efficient release of entrapped agents in response to acidic pH. The pH-sensitive anionic liposomes showed high dispersion stability at neutral pH, but the fluidity of the bilayer membrane was enhanced in an acidic environment. These liposomes were rather simple and were composed of dimyristoylphosphatidylcholine (DMPC), an anionic bilayer membrane component, and polyoxyethylene sorbitan monostearate (Tween 80). In particular, the present pH-sensitive anionic liposomes showed higher temporal stability than those of conventional DMPC/DPPC liposomes. We found that pHsensitive properties strongly depended on the molecular structure, pKa value, and amount of an incorporated anionic bilayer membrane component, such as sodium oleate (SO), dimyristoylphosphatidylserine (DMPS), or sodium β-sitosterol sulfate (SS). These results provide an opportunity to manipulate liposomal stability in a pH-dependent manner, which could lead to the formulation of a high performance drug delivery system (DDS). |
| Databáze: | OpenAIRE |
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